SML1074

R1530

≥98% (HPLC)

• Sinónimos: 5-(2-Chlorophenyl)-7-fluoro-1,2-dihydro-8-methoxy-3-methyl-pyrazolo[3,4-b][1,4]benzodiazepine
• Fórmula empírica (notación de Hill): C₁₈H₁₄ClFN₄O
• Número CAS: 882531-87-5
• Peso molecular: 356.78
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825456
• MDL number: MFCD23704870
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• assay: ≥98% (HPLC)
• form: powder
• drug control: regulated under CDSA - not available from Sigma-Aldrich Canada
• color: , white to yellow to light brown
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: ClC1=CC=CC=C1C2=NC3=C(C)NN=C3NC4=C2C=C(F)C(OC)=C4
• InChI: 1S/C18H14ClFN4O/c1-9-16-18(24-23-9)21-14-8-15(25-2)13(20)7-11(14)17(22-16)10-5-3-4-6-12(10)19/h3-8H,1-2H3,(H2,21,23,24)
• InChI key: UOVCGJXDGOGOCZ-UHFFFAOYSA-N
• Gene Information: human ... AURKA(6790), FGFR1(2260), FGFR2(2263), FLT1(2321), FLT3(2322), FLT4(2324), KDR(3791), PDGFRB(5159), PLK4(10733)

Descripción

Biochem/physiol Actions

R1530 is a multi-kinase inhibitor and an anti tumor agent.

R1530 is a multi-kinase inhibitor with activity against several kinases associated with tumor growth and angiogenesis, including VEGFR, FGFR, PDGFR, Chk2 and Cdk2. In tumor cells, R1530 inhibits tubulin polyerization and mitotic checkpoint function, resulting in polyploidy. The compound R1530 inhibits tumor growth and angiogenesis in animal models.

Información de seguridad

• Pictogramas: GHS07
• Palabra de advertencia: Warning
• Códigos de peligro: H315,H319,H335
• Indicaciones de precaución: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órganos diana: Respiratory system
• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable