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SML0883

Sigma-Aldrich

HIF-2 Antagonist 2

≥98% (HPLC)

Sinónimos:

N-(3-Chloro-5-fluorophenyl)-4-nitrobenzo[c][1,2,5]oxadiazol-5-amine, TC-S7009

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5 MG
$72.10
25 MG
$417.00

$72.10

Precio de catálogo$103.00Ahorre 30 %

Fecha estimada de envío22 de mayo de 2025

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5 MG
$72.10
25 MG
$417.00

About This Item

Fórmula empírica (notación de Hill):
C12H6ClFN4O3
Número de CAS:
1422955-31-4
Peso molecular:
308.65
Código UNSPSC:
12352200
NACRES:
NA.77

$72.10

Precio de catálogo$103.00Ahorre 30 %

Fecha estimada de envío22 de mayo de 2025

Solicitar un pedido a granel

Nivel de calidad

100

Ensayo

≥98% (HPLC)

Formulario

powder

color

white to beige

solubilidad

DMSO: 15 mg/mL, clear

temp. de almacenamiento

room temp

cadena SMILES

Fc1cc(cc(c1)Nc2c(c3n[o]nc3cc2)[N+](=O)[O-])Cl

InChI

1S/C12H6ClFN4O3/c13-6-3-7(14)5-8(4-6)15-10-2-1-9-11(17-21-16-9)12(10)18(19)20/h1-5,15H

Clave InChI

CDQUJZKBRAFWNG-UHFFFAOYSA-N

Acciones bioquímicas o fisiológicas

HIF-2α antagonist.
Hypoxia inducible transcription factors (HIF) control gene expression when oxygen availability is low and are associated with the onset and progression of a variety of cancers. They are heterodimers of an HIF-α (HIF-1α, HIF-2α also known as EPAS-1, or HIF-3α) and aryl hydrocarbon receptor nuclear translocator (ARNT, also known as HIF-β). N-(3-Chloro-5-fluorophenyl)-4-nitrobenzo[c][1,2,5]oxadiazol-5-amine is a highly selective antagonist of HIF-2 heterodimerization, DNA-binding activity, and target gene transcription. It binds the HIF-2α PAS-B domain with a KD ~80 nM compared to a KD > 5000 nM for the HIF-1α PAS-B domain.

Características y beneficios

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Código de clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Clase de riesgo para el agua (WGK)

WGK 3

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Certificados de análisis (COA)

Lot/Batch Number
0000247051
026M4615V
113M4613V

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Isabelle Westerlund et al.
Biochemical and biophysical research communications, 508(4), 1233-1239 (2018-12-20)
The hypoxia inducible transcription factor EPAS1/HIF2α has been described as an oncogene and a potential therapeutic target in neuroblastoma. Our analysis of several neuroblastoma tumour expression datasets does not support an oncogenic role, instead EPAS1 expression is associated with better
Kyoko Endo et al.
International journal of molecular sciences, 21(1) (2019-12-22)
Previous studies have reported the up-regulation of the two-pore domain K+ channel K2P5.1 in the CD4+ T cells of patients with multiple sclerosis (MS) and rheumatoid arthritis (RA), as well as in a mouse model of inflammatory bowel disease (IBD).
Bo Zhang et al.
Cells, 11(16) (2022-08-27)
Hypoxia-inducible factor (HIF) directly activates the transcription of metabolic enzymes in response to hypoxia to reprogram cellular metabolism required for tumor cell proliferation. Through analyzing glutamate-linked aminotransferases, we here identified glutamate pyruvate transaminase 2 (GPT2) as a direct HIF-2 target
Fumihito Hikage et al.
Endocrinology, 160(1), 20-35 (2018-11-06)
Thyroid-associated orbitopathy (TAO) is a disfiguring periocular connective tissue disease associated with autoimmune thyroid disorders. It is a potentially blinding condition, for which no effective pharmacological treatment has been established. Despite a suggested role played by autoimmune thyrotropin receptor activation

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