SML0653

Capecitabine

≥98% (HPLC), DNA/RNA synthesis inhibitor, powder

• Sinónimos: 5′-Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine, Ro-9-1978
• Fórmula empírica (notación de Hill): C₁₅H₂₂FN₃O₆
• Número CAS: 154361-50-9
• Peso molecular: 359.35
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825576
• NACRES: NA.77
• MDL number: MFCD00930626
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• Nombre del producto: Capecitabine, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D +80 to +100°, c = 0.5 in methanol
• color: white to beige
• solubility: H₂O: 10 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• SMILES string: O[C@H]1[C@@H](O)[C@H](N2C(N=C(NC(OCCCCC)=O)C(F)=C2)=O)O[C@@H]1C
• InChI: 1S/C15H22FN3O6/c1-3-4-5-6-24-15(23)18-12-9(16)7-19(14(22)17-12)13-11(21)10(20)8(2)25-13/h7-8,10-11,13,20-21H,3-6H2,1-2H3,(H,17,18,22,23)/t8-,10-,11-,13-/m1/s1
• InChI key: GAGWJHPBXLXJQN-UORFTKCHSA-N
• Gene Information: human ... TYMS(7298)

Descripción

Application

Capecitabine has been used:

• in combination with gemcitabine to achieve glutamine deprivation by enhancing the sensitivity of expression in pancreatic ductal adenocarcinoma (PDAC) cells to inhibitors of glutamine metabolism and study its effect on PDAC cell survival
• to study the drug metabolic function in a two-organ microfluidic system
• as an anti-cancer agent to study its cytotoxic activity alone or in combination with B87 on cancer cells

Biochem/physiol Actions

Capecitabine is an anti-cancer drug, a prodrug of doxifluridine, metabolized to 5-fluorouracil at the tumor site.

Capecitabine is an anti-cancer drug, a prodrug of doxifluridine, metabolized to 5-fluorouracil at the tumor site. The activation of capecitabine follows a pathway with three enzymatic steps and two intermediary metabolites, 5′-Deoxy-5-fluorocytidine (5′-DFCR) and 5′-Deoxy-5-fluorouridine (5′-DFUR), to form 5-fluorouracil.

Información de seguridad

• Pictogramas: GHS08
• Palabra de advertencia: Danger
• Códigos de peligro: H341,H350,H360FD
• Indicaciones de precaución: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Carc. 1B - Muta. 2 - Repr. 1B
• Clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable