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SML0602

Sigma-Aldrich

Propiverine hydrochloride

≥98% (HPLC)

Sinónimos:

α,α-Diphenyl-α-propoxyacetic acid hydrochloride 1-methyl-4-piperidyl ester, α-Phenyl-α-propoxybenzeneacetic acid 1-methyl-4-piperidinyl ester hydrochloride, (1-Methylpiperidin-1-ium-4-yl) 2,2-diphenyl-2-propoxyacetate chloride, 1-Methyl-4-piperidyl diphenylpropoxyacetate hydrochloride

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$63.70
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5 MG
$63.70
100 MG
$188.10

About This Item

Fórmula empírica (notación de Hill):
C23H29NO3 · HCl
Número de CAS:
Peso molecular:
403.94
Código UNSPSC:
12352200
NACRES:
NA.77

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Nivel de calidad

Ensayo

≥98% (HPLC)

Formulario

powder

condiciones de almacenamiento

desiccated

color

white to beige

solubilidad

H2O: 5 mg/mL, clear (warmed)

temp. de almacenamiento

2-8°C

cadena SMILES

[Cl-].[N+H]1(CCC(CC1)OC(=O)C(OCCC)(c3ccccc3)c2ccccc2)C

InChI

1S/C23H29NO3.ClH/c1-3-18-26-23(19-10-6-4-7-11-19,20-12-8-5-9-13-20)22(25)27-21-14-16-24(2)17-15-21;/h4-13,21H,3,14-18H2,1-2H3;1H

Clave InChI

KFUJMHHNLGCTIJ-UHFFFAOYSA-N

Descripción general

Propiverine hydrochloride drug is a tertiary amine with spasmolytic and analgesic properties. This drug exerts neurotropic and musculotropic effects on the urinary bladder and smooth muscles.[1] Propiverine hydrochloride has a half-life of 20 hours.[2]

Acciones bioquímicas o fisiológicas

Propiverine is an antimuscarinic drug used for the treatment of overactive blaqdder and urinary incontinence. Propiverine and/or its metabolites also have calcium channel blocking properties in addition to antimuscarinic activity, which may contribute to the clinical activity.
Propiverine is an antimuscarinic drug used for the treatment of overactive blaqdder and urinary incontinence.

Características y beneficios

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictogramas

CorrosionExclamation mark

Palabra de señalización

Danger

Frases de peligro

Clasificaciones de peligro

Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

Órganos de actuación

Respiratory system

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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F Donath et al.
International journal of clinical pharmacology and therapeutics, 49(6), 353-365 (2011-05-27)
Two comprehensively designed mono-centric ECG studies were performed to investigate the influence of propiverine hydrochloride and its main metabolite propiverine-N-oxide on cardiac function with regard to QTc prolongation, QTc dispersion and T-wave shape. The first study was conducted on 24
Heinrich Schulte-Baukloh et al.
Journal of pediatric urology, 8(4), 386-392 (2011-09-13)
To evaluate prospectively the efficacy and tolerability of propiverine for long-term treatment of neurogenic detrusor overactivity (NDO) in children. 17 children and adolescents with NDO (10 female, 7 male; average age at last consultation 13.0 years) were evaluated during long-term
Kimio Sugaya et al.
International journal of urology : official journal of the Japanese Urological Association, 19(5), 480-483 (2012-01-10)
It is not uncommon for patients with spinal cord injury to have both detrusor overactivity during the storage phase and detrusor underactivity during the voiding phase. However, there has been no information about the efficacy of combined treatment with cholinesterase
A placebo-controlled, multicentre study comparing the tolerability and eYcacy of propiverine and oxybutinin in patients with urgency and urge incontinence.
Madersbacher H, et al.
BJU International, 84, 646-651 (1999)
Efficacy, tolerability and safety profile of propiverine in the treatment of the overactive bladder (non-neurogenic and neurogenic)
Madersbacher H, et al.
World Journal of Urology, 19(5), 324-335 (2001)

Artículos

Muscarinic acetylcholine receptors mediate acetylcholine actions in CNS and non-nervous tissues, crucial for cell signaling.

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