SML0552

Tirapazamine

≥98% (HPLC), Pro-apoptotic, powder

• Sinónimos: 4-Hydroxy-1-oxido-1,2,4-benzotriazin-1-ium-3-imine, SR 259075, SR 4233, Tirazone, Win 59075
• Fórmula empírica (notación de Hill): C₇H₆N₄O₂
• Número CAS: 27314-97-2
• Peso molecular: 178.15
• UNSPSC Code: 12352116
• PubChem Substance ID: 329825548
• NACRES: NA.77
• MDL number: MFCD00132954
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• Nombre del producto: Tirapazamine, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: , orange to dark orange-red
• solubility: DMSO: 10 mg/mL, clear
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: Nc1n[n+]([O-])c2ccccc2[n+]1[O-]
• InChI: 1S/C7H6N4O2/c8-7-9-11(13)6-4-2-1-3-5(6)10(7)12/h1-4H,(H2,8,9)
• InChI key: ORYDPOVDJJZGHQ-UHFFFAOYSA-N

Descripción

Application

Tirapazamine has been used to evaluate its cytotoxic effect on U-251 MG (glioblastoma cell line) cell viability.

Biochem/physiol Actions

Under hypoxic conditions, tirapazamine is a potent cytotoxic agent that induces apoptosis by inducing breaks in single and double stranded DNA, as well as chromosomal breaks. The compound sensitizes cells to other ionizing radiation and other cytotoxic agents like cisplatin.

Under hypoxic conditions, tirapazamine is a potent cytotoxic agent..

Información de seguridad

• Pictogramas: GHS07
• Palabra de advertencia: Warning
• Códigos de peligro: H315,H319,H335
• Indicaciones de precaución: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órganos diana: Respiratory system
• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable