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SML0491

Ritonavir

≥98% (HPLC), HIV protease inhibitor, powder

Sinónimos:

A-84538, ABT-538, Abbott 84538

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Talla/SKUDisponibilidadPrecio
10 mg
Comprobar disponibilidad del carrito
$93.70
50 mg
Comprobar disponibilidad del carrito
$379.00

Acerca de este artículo

Fórmula empírica (notación de Hill):
C37H48N6O5S2
Número CAS:
Peso molecular:
720.94
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

$93.70


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Nombre del producto

Ritonavir, ≥98% (HPLC)

Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL (clear solution, warmed)

storage temp.

room temp

SMILES string

O=C(OCC1=CN=CS1)N[C@H]([C@@H](O)C[C@@H](NC([C@@H](NC(N(CC2=CSC(C(C)C)=N2)C)=O)C(C)C)=O)CC3=CC=CC=C3)CC4=CC=CC=C4

InChI

1S/C37H48N6O5S2/c1-24(2)33(42-36(46)43(5)20-29-22-49-35(40-29)25(3)4)34(45)39-28(16-26-12-8-6-9-13-26)18-32(44)31(17-27-14-10-7-11-15-27)41-37(47)48-21-30-19-38-23-50-30/h6-15,19,22-25,28,31-33,44H,16-18,20-21H2,1-5H3,(H,39,45)(H,41,47)(H,42,46)/t28-,31-,32-,33-/m0/s1

InChI key

NCDNCNXCDXHOMX-XGKFQTDJSA-N

Application

Ritonavir has been used:
  • as a human immunodeficiency virus (HIV) protease inhibitor to study its effects on placental endocrine function
  • as an HIV protease inhibitor to study its effects on reduction of tetrazolium dye in human embryonic kidney cells
  • as an organic anion transporting polypeptide (OATP) inhibitor to study its effect on hepatic uptake of bergapten and imperatorin

Biochem/physiol Actions

Ritonavir is an HIV protease inhibitor now used frequently as a booster of other protease inhbitors. Ritonavir inhibits cytochrome P450-3A4 (CYP3A4), a liver enzyme that normally metabolizes protease inhibitors. It has also been investigated as a possible anti-cancer agent.
Ritonavir is an HIV protease inhibitor; antiretroviral.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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Y00007141604803PHR1734
vibrant-m

Y0000714

Ritonavir

USP

USP

1604803

Ritonavir

description

≥98% (HPLC)

description

European Pharmacopoeia (EP) Reference Standard

description

United States Pharmacopeia (USP) Reference Standard

description

Pharmaceutical Secondary Standard; Certified Reference Material

form

powder

form

-

form

powder

form

powder

assay

≥98% (HPLC)

assay

-

assay

-

assay

-

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

300

storage temp.

room temp

storage temp.

2-8°C

storage temp.

-

storage temp.

2-30°C

solubility

DMSO: 10 mg/mL (clear solution, warmed)

solubility

methanol: soluble

solubility

ethanol: freely soluble, methanol: freely soluble, acetonitrile: slightly soluble, water: practically insoluble, methylene chloride: freely soluble

solubility

methylene chloride: freely soluble, ethanol: freely soluble, acetonitrile: slightly soluble, water: practically insoluble, methanol: freely soluble

color

white to beige

color

-

color

white to tan

color

white to tan


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Warning

Códigos de peligro

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Clase de almacenamiento

11 - Combustible Solids

Punto de inflamación (°F)

Not applicable

Punto de inflamación (°C)

Not applicable



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