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SML0455

Sigma-Aldrich

1,2,3,4,5,6-Hexabromocyclohexane

≥98% (HPLC)

Sinónimos:

1,2,3,4,5,6-Hexabromocyclohexane, Benzene hexabromide, NSC 7908

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About This Item

Fórmula empírica (notación de Hill):
C6H6Br6
Número de CAS:
1837-91-8
Peso molecular:
557.54
MDL number:
MFCD00059127
UNSPSC Code:
12352202
PubChem Substance ID:
329824734
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL (clear solution, warmed)

storage temp.

room temp

SMILES string

BrC1C(Br)C(Br)C(Br)C(Br)C1Br

InChI

1S/C6H6Br6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-6H

InChI key

QFQZKISCBJKVHI-UHFFFAOYSA-N

Biochem/physiol Actions

1,2,3,4,5,6-hexabromocyclohexane binds directly to a pocket within the kinase domain of JAK2 and inhibits autophosphorylation. The compound also blocks growth hormone induced JAK2 autophosphorylation without affecting EFGR autophosphorylation.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302,H319

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Kotaro Horiguchi et al.
Cell and tissue research, 364(2), 395-404 (2015-11-18)
Secretion of hormones by the anterior pituitary gland can be stimulated or inhibited by paracrine factors that are produced during inflammatory reactions. The inflammation cytokine interferon-gamma (IFN-γ) is known to inhibit corticotropin-releasing factor (CRF)-stimulated adrenocorticotropin (ACTH) release but its signaling
Jeffrey D Kittilson et al.
Frontiers in endocrinology, 2, 30-30 (2011-01-01)
Previously, we found that the teleost fish, rainbow trout, possesses two growth hormone receptor (GHR) subtypes that display distinct ligand-binding and agonist-induced regulation features. In this study, we used Chinese hamster ovary-K1 cells stably transfected individually with the two trout
Anshu Agrawal et al.
Aging, 4(9), 648-659 (2012-10-16)
Advancing age leads to significant decline in immune functions. IL-21 is produced primarily by T follicular helper (Tfh) cells and is required for effective immune cell functions. Here we compared the induction of IL-21 in aged and young subjects. Our
Xue Jiang et al.
Frontiers in endocrinology, 11, 20-20 (2020-02-23)
In mammals, local production of tumor necrosis factor α (TNFα) inhibits growth hormone (GH)-induced IGF-I expression at tissue level and contributes to GH resistance caused by sepsis/endotoxemia and inflammation. Although the loss of GH responsiveness can be mediated by a
Shirley C Mills et al.
Cellular signalling, 28(4), 316-324 (2016-01-26)
Chemotaxis or directed cell migration is mediated by signalling events initiated by binding of chemokines to their cognate receptors and the activation of a complex signalling cascade. The molecular signalling pathways involved in cell migration are important to understand cancer
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