SML0393

QNZ46

≥98% (HPLC)

• Sinónimos: 4-[6-Methoxy-2-[(1E)-2-(3-nitrophenyl)ethenyl]-4-oxo-3(4H)-quinazolinyl]-Benzoic acid
• Fórmula empírica (notación de Hill): C₂₄H₁₇N₃O₆
• Número de CAS: 1237744-13-6
• Peso molecular: 443.41
• MDL number: MFCD22666391
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825390
• NACRES: NA.77

Propiedades

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 5 mg/mL (warmed; clear solution)
• storage temp.: room temp
• SMILES string: COc1ccc2N=C(\C=C\c3cccc(c3)[N+]([O-])=O)N(C(=O)c2c1)c4ccc(cc4)C(O)=O
• InChI: 1S/C24H17N3O6/c1-33-19-10-11-21-20(14-19)23(28)26(17-8-6-16(7-9-17)24(29)30)22(25-21)12-5-15-3-2-4-18(13-15)27(31)32/h2-14H,1H3,(H,29,30)/b12-5+
• InChI key: GNLVJIICVWDSNI-LFYBBSHMSA-N

Descripción

Biochem/physiol Actions

QNZ46 is a noncompetitive inhibitor of GluN2C/D containing NMDA receptors. KD and IC₅₀ values for binding and inhibition of GluN1/Glun2D receptors by QNZ46 are 4.9 and 3.9 μM, respectively. QNZ46 does not compete for binding of glutamate or glycine, but QNZ46 receptor binding requires the binding of glutamate to the GluN2 subunit.

Features and Benefits

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable