SML0341
Importazole
≥98% (HPLC), importin-β transport receptor inhibitor, powder
Oferta disponible
Sinónimos:
N-(1-Phenylethyl)-2-(pyrrolidin-1-yl)quinazolin-4-amine
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| Talla/SKU | Disponibilidad | Precio |
|---|---|---|
5 mg | Disponible para enviar HOYdesdeMILWAUKEE | $141.00 |
25 mg | Disponible para enviar HOYdesdeMILWAUKEE | $557.00 |
Acerca de este artículo
Nombre del producto
Importazole, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: >5 mg/mL
storage temp.
2-8°C
SMILES string
CC(C1=CC=CC=C1)NC2=NC(N3CCCC3)=NC4=C2C=CC=C4
InChI
1S/C20H22N4/c1-15(16-9-3-2-4-10-16)21-19-17-11-5-6-12-18(17)22-20(23-19)24-13-7-8-14-24/h2-6,9-12,15H,7-8,13-14H2,1H3,(H,21,22,23)
InChI key
HKGJEZIGDHFJFL-UHFFFAOYSA-N
Application
- to inhibit importin-β and to elucidate the mechanism of enhanced nuclear localization of heat shock protein 70 (HSP70) by vaccinia-related kinase 3 (VRK3)
- to treat COS?7 cells transfected with the expressing vectors of WT HNF4α , S78A, and S78D to study its effect
- as a KPNB inhibitor to determine whether CREB-regulated co-activator 1 (CRTC1) would be escorted into the nucleus by the classical nuclear localizing sequence (NLS)- dependent machinery
- as a functional inhibitor of Importin β in embryo treatment
- as an importin inhibitor to treat the transfected H1299 cells to block nuclear translocation of phosphorylated p53-RS
Biochem/physiol Actions
1 of 1
Este artículo | |||
|---|---|---|---|
| description ≥98% (HPLC) | description A cell-permeable diaminoquinazoline compound that selectively blocks importin-β-mediated nuclear import of NLS bearing cargos in a reversible manner. | description ≥98% (HPLC) | description ≥98% (HPLC) |
| form powder | form solid | form powder | form powder |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: >5 mg/mL | solubility DMSO: 25 mg/mL, clear, colorless | solubility DMSO: 2 mg/mL, clear | solubility DMSO: 5 mg/mL, clear (warmed) |
| color white to beige | color white | color white to beige | color white to beige |
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Clase de almacenamiento
11 - Combustible Solids
¿Qué está pasando?
WGK 3
Punto de inflamación (°F)
Not applicable
Punto de inflamación (°C)
Not applicable
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