SML0259

Catharanthine

≥95% (HPLC)

• Sinónimos: (+)-3,4-Didehydrocoronaridine, (2α,5β,6α,18β)-3,4-Didehydroibogamine-18-carboxylic acid methyl ester, 7-Ethyl-9,10,12,13-tetrahydro-6,9-methano-5H-pyrido[1′,2′:1,2]azepino[4,5-b]indole-6(6aH)-carboxylic acid methyl ester
• Fórmula empírica (notación de Hill): C₂₁H₂₄N₂O₂
• Número CAS: 2468-21-5
• Peso molecular: 336.43
• NACRES: NA.77
• PubChem Substance ID: 329825267
• UNSPSC Code: 12352200
• MDL number: MFCD01753356
• Assay: ≥95% (HPLC)
• Form: powder

Propiedades

• assay: ≥95% (HPLC)
• form: powder
• optical activity: [α]/D +30 to +38° (c=0.5, CDCl3)
• color: white to beige
• solubility: DMSO: 5 mg/mL (clear solution; warmed)
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: CCC1=C[C@@H]2C[N@H]3CCc4c([nH]c5ccccc45)[C@@](C2)([C@@H]13)C(=O)OC
• InChI: 1S/C21H24N2O2/c1-3-14-10-13-11-21(20(24)25-2)18-16(8-9-23(12-13)19(14)21)15-6-4-5-7-17(15)22-18/h4-7,10,13,19,22H,3,8-9,11-12H2,1-2H3/t13-,19+,21-/m0/s1
• InChI key: CMKFQVZJOWHHDV-NQZBTDCJSA-N

Descripción

Biochem/physiol Actions

Catharanthine is a precursor of the anti-tumor drugs vinblastine and vincristine, formed by dimerization of catharanthine with vindoline. Catharanthine itself is an inhibitor of tubulin self-assembly into microtubules, although not so potent as vinblastine or vincristine. Catharanthine also has anticholinergic activity. It showed muscarinic antagonism at 10 microM and fully inhibited nicotinic receptor mediated diaphragm contractions with an IC₅₀ of 59.6 microM.

Catharanthine is a precursor of the anti-tumor drugs vinblastine and vincristine..Catharanthine is an inhibitor of tubulin self-assembly into microtubules.

Información de seguridad

• Pictogramas: GHS07
• Palabra de advertencia: Warning
• Códigos de peligro: H302
• Indicaciones de precaución: P301 + P312 + P330
• Hazard Classifications: Acute Tox. 4 Oral
• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable