SML0066

NGB 2904 hydrochloride

≥98% (HPLC)

• Sinónimos: N-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide hydrochloride
• Fórmula empírica (notación de Hill): C₂₈H₂₉Cl₂N₃O·HCl
• Número de CAS: 189061-11-8
• Peso molecular: 530.92
• Número MDL: MFCD09971107
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329825130
• NACRES: NA.77

Propiedades

• Ensayo: ≥98% (HPLC)
• Formulario: powder
• condiciones de almacenamiento: desiccated
• color: white to tan
• solubilidad: DMSO: ≥25 mg/mL
• temp. de almacenamiento: 2-8°C
• cadena SMILES: Cl.Clc1cccc(N2CCN(CCCCNC(=O)c3ccc-4c(Cc5ccccc-45)c3)CC2)c1Cl
• InChI: 1S/C28H29Cl2N3O.ClH/c29-25-8-5-9-26(27(25)30)33-16-14-32(15-17-33)13-4-3-12-31-28(34)21-10-11-24-22(19-21)18-20-6-1-2-7-23(20)24;/h1-2,5-11,19H,3-4,12-18H2,(H,31,34);1H
• Clave InChI: PFIWYJNBKGCVFM-UHFFFAOYSA-N

Descripción

Aplicación

NGB 2904 hydrochloride may be used in cell signaling studies.

Acciones bioquímicas o fisiológicas

Inhibition of dopamine D₃ receptor function by NGB 2904 increases spontaneous locomotor activity in rodents.[1]

NGB 2904 hydrochloride is a potent and selective dopamine D3 receptor antagonist

NGB 2904 is a potent and selective dopamine D3 receptor antagonist with a D3/D2 ratio of 800 for rat and high binding affinity (1.4 nM) at the hD3 receptor with 150-fold selectivity for primate D3 receptors over primate D2L receptors. It attenuates the rewarding effects of cocaine and methamphetamine.

Características y beneficios

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable