SML0020

BX471

≥98% (HPLC)

• Sinónimos: N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-urea, ZK-811752
• Fórmula empírica (notación de Hill): C₂₁H₂₄ClFN₄O₃
• Número de CAS: 217645-70-0
• Peso molecular: 434.89
• Código UNSPSC: 51111800
• NACRES: NA.77

Propiedades

• Ensayo: ≥98% (HPLC)
• Formulario: powder
• condiciones de almacenamiento: desiccated
• color: white to tan
• solubilidad: DMSO: ≥25 mg/mL
• emisor: Bayer
• temp. de almacenamiento: 2-8°C
• cadena SMILES: Fc1ccc(cc1)CN2C[C@H](N(CC2)C(=O)COc3c(cc(cc3)Cl)NC(=O)N)C
• InChI: 1S/C21H24ClFN4O3/c1-14-11-26(12-15-2-5-17(23)6-3-15)8-9-27(14)20(28)13-30-19-7-4-16(22)10-18(19)25-21(24)29/h2-7,10,14H,8-9,11-13H2,1H3,(H3,24,25,29)/t14-/m1/s1
• Clave InChI: XQYASZNUFDVMFH-CQSZACIVSA-N

Descripción

Aplicación

BX471 has been used in chemotaxis assay to study the responses of HEK293 cells expressing human C-C motif chemokine receptor 1 (CCR1) to CC motif ligand 3 (CCL3)-induced cell migration.[1] It has also been used as a CCR1 inhibitor to assess the effects of CCR1 on the migration and epithelial-mesenchymal transition (EMT).[2]

Acciones bioquímicas o fisiológicas

BX471 blocks CCR1 and downregulates the mRNA expression of ICAM-1, P-selectin and E-selectin.[3] It decreases the inflammatory responses in sepsis,[3] prevents monocyte recruitment in inflammation sites in rheumatoid arthritis patients[4] and inhibits interstitial leukocyte recruitment and fibrosis in mouse model of lupus nephritis.[5]

BX471 is a CCR1 Antagonist

BX471 is an orally active, CCR-1 specific antagonist. It displaces the endogenous CCR-1 ligands MIP-1a, RANTES and MCP-3 (Ki range 1-5 nM). BX471 inhibits CCR-1 effects in leukocytes, including calcium mobilization and migration.

Características y beneficios

This compound is featured on the Chemokine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable