SCP0002

Acetyl-Amyloid β 25-35

• Fórmula empírica (notación de Hill): C₄₇H₈₃N₁₃O₁₅S₁
• Peso molecular: 1102.31
• NACRES: NA.32
• UNSPSC Code: 12352202

Propiedades

• assay: ≥95% (HPLC)
• form: lyophilized
• composition: Peptide Content, ≥70%
• storage condition: protect from light
• UniProt accession no.: P05067
• storage temp.: −20°C
• Gene Information: human ... APP(351)

Descripción

General description

Amyloid-β (Aβ) peptides are a major component of the senile plaques characteristic of the Alzheimer brain. It is a type- I transmembrane protein. The amyloid β precursor protein is cleaved to amyloid peptides 36-43 amino acids in length. Aβ (25-35) represents the region that aggregates during plaque formation and is a functional domain implicated in both neurotrophic and neurotoxic effects. The gene encoding amyloid-β is localized on human chromosome 21. Acetylation may improve stability in in vitro and in vivo assays.

Application

Acetyl-Amyloid β 25-35 has been used to prepare rat models with Alzheimer′s disease.

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable