Forkhead box P3 (FOXP3) is located on human chromosome Xp11.23-Xq13.3. FOXP3 is a putative DNA-binding protein and is a member of the forkhead family. The protein is mainly expressed in the CD4+CD25+ regulatory T-cell subsets.
Immunogen
Purified recombinant fragment of human Foxp3 expressed in E.coli. Mouse monoclonal antibody raised against Foxp3
Application
Monoclonal Anti-FOXP3 antibody has been used in immunohistochemistry (IHC).
Biochem/physiol Actions
Forkhead box P3 (FOXP3) plays an essential role in the development of CD4+CD25+ regulatory T cells and regulates immune homeostasis. It also acts as a transcriptional repressor. Polyadenylation signal mutation of the gene leads to immune dysregulation, polyendocrinopathy, enteropathy and X-linked inheritance (IPEX). Abnormalities in the gene expression are also associated with the pathogenesis of autism spectrum disorders (ASD) and unexplained recurrent spontaneous abortion (URSA).
Physical form
Ascitic fluid containing 0.03% sodium azide.
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Current opinion in rheumatology, 15(4), 430-435 (2003-06-24)
Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX) is one of a group of clinical syndromes that present with multisystem autoimmune disease suggesting a phenotype of immune dysregulation. Clinically, IPEX manifests most commonly with diarrhea, insulin-dependent diabetes mellitus, thyroid disorders
The mouse scurfy gene, Foxp3, and its human orthologue, FOXP3, which maps to Xp11.23-Xq13.3, were recently identified by positional cloning. Point mutations and microdeletions of the FOXP3 gene were found in the affected members of eight of nine families with
Correlation between protein expression of FOXP3 and level of FOXP3 promoter methylation in recurrent spontaneous abortion
Hou Wenhui, et al.
Journal of Obstetrics and Gynaecology : The Journal of the Institute of Obstetrics and Gynaecology, 42(11), 1439-1444 (2016)
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