SAB4502602

Anti-CYCLIN D1, C-Terminal antibody produced in rabbit

affinity isolated antibody

• Sinónimos: BCL-1 oncogene, BCL1, CYL-1, G1/S-specific cyclin D1, cyclin D1
• MDL number: MFCD00239664
• UNSPSC Code: 12352203
• NACRES: NA.41
• conjugate: unconjugated
• application: ELISA; IHC; WB
• clone: polyclonal
• species reactivity: rat, mouse, human
• citations: 8
• technique(s): ELISA: 1:5000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000

Propiedades

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 33 kDa
• species reactivity: rat, mouse, human
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:5000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI accession no.: P24385
• UniProt accession no.: P24385
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... CCND1(595)

Descripción

General description

Anti-CYCLIN D1 antibody detects endogenous levels of total CYCLIN D1 protein.

The CCND1 (cyclin D1) gene is mapped to human chromosome 11q13.3.

Immunogen

The antiserum was produced against synthesized peptide derived from human Cyclin D1.

Immunogen Range: 246-295

Application

Anti-CYCLIN D1, C-Terminal antibody produced in rabbit has been used in western blotting analysis.[1]

Biochem/physiol Actions

CCND1 (cyclin D1) regulates cell cycle by mediating the G1 to S phase transition. The gene gets activated by β-catenin and participates in the process of tumor formation. Upregulation of the gene is observed in cancer such as lung, breast, colon, hematopoietic and prostate carcinomas, and promotes contact independent cell growth. Variation in CCND1 contributes to increased occurrence of colorectal cancer.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable