SAB4300517

Anti-CTTN (Ab-421) antibody produced in rabbit

affinity isolated antibody

• Sinónimos: Anti-EMS1 antibody produced in rabbit, Anti-FLJ34459 antibody produced in rabbit, Anti-cortactin antibody produced in rabbit
• Código UNSPSC: 12352203

Propiedades

• origen biológico: rabbit
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• Formulario: buffered aqueous solution
• mol peso: ~85 kDa
• reactividad de especies: mouse, human
• concentración: 1 mg/mL
• técnicas: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
• isotipo: IgG
• secuencia del inmunógeno: (P-I-Y-E-D)
• Nº de acceso NCBI: NP_005222.2
• Nº de acceso UniProt: Q14247
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... CTTN(2017)

Descripción

Inmunógeno

Peptide sequence around aa. 419-423 (P-I-Y-E-D), according to the protein CTTN.

Características y beneficios

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Descripción de destino

Cortactin is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Two splice variants that encode different isoforms have been identified for this gene.

Forma física

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable