SAB4300121
Anti-phospho-CHEK2 (pSer516) antibody produced in rabbit
affinity isolated antibody
Sinónimos:
Anti-CDS1 antibody produced in rabbit, Anti-CHK2 antibody produced in rabbit, Anti-CHK2 checkpoint homolog (S. pombe) antibody produced in rabbit, Anti-HuCds1 antibody produced in rabbit, Anti-LFS2 antibody produced in rabbit
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100 μG
$395.00
$395.00
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100 μG
$395.00
About This Item
Código UNSPSC:
12352203
NACRES:
NA.41
$395.00
Check Cart for Availability
origen biológico
rabbit
conjugado
unconjugated
forma del anticuerpo
affinity isolated antibody
tipo de anticuerpo
primary antibodies
clon
polyclonal
Formulario
buffered aqueous solution
mol peso
~62 kDa
reactividad de especies
human
concentración
1 mg/mL
técnicas
western blot: 1:500-1:1000
isotipo
IgG
secuencia del inmunógeno
(Q-P-SP-T-S)
Nº de acceso NCBI
Nº de acceso UniProt
Condiciones de envío
wet ice
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
phosphorylation (pSer516)
Información sobre el gen
human ... CHEK2(11200)
Inmunógeno
Peptide sequence around phosphorylation site of serine 516 (Q-P-S(p)-T-S), according to the protein CHEK2.
Características y beneficios
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Descripción de destino
In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by Chk2 gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Three transcript variants encoding different isoforms have been found for this gene.
Forma física
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
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Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Nucleic acids research, 47(4), 1797-1813 (2018-12-13)
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Bo Liu et al.
The international journal of biochemistry & cell biology, 109, 40-58 (2019-02-03)
The role of protein phosphatase 2ACα (PP2ACα) in brain development is poorly understood. To understand the function of PP2ACα in neurogenesis, we inactivated Pp2acα gene in the central nervous system (CNS) of mice by Cre/LoxP system and generated the PP2ACα
Shiyuan Hong et al.
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High-risk human papillomaviruses (HPVs) constitutively activate ataxia telangiectasia mutated (ATM) and ataxia telangiectasia- and Rad3-related (ATR) DNA damage repair pathways for viral genome amplification. HPVs activate these pathways through the immune regulator STAT-5. For the ATR pathway, STAT-5 increases expression
Xingyi Guo et al.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 28(8), 1308-1315 (2019-06-05)
Pathogenic variants in susceptibility genes lead to increased breast cancer risk. To identify coding variants associated with breast cancer risk, we conducted whole-exome sequencing in genomic DNA samples from 831 breast cancer cases and 839 controls of Chinese women. We
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