SAB4300031

Anti-phospho-GATA1 (pSer³¹⁰) antibody produced in rabbit

affinity isolated antibody

• Sinónimos: Anti-ERYF1 antibody produced in rabbit, Anti-GATA binding protein 1 (globin transcription factor 1) antibody produced in rabbit, Anti-GF-1 antibody produced in rabbit, Anti-GF1 antibody produced in rabbit, Anti-NFE1 antibody produced in rabbit
• MDL number: MFCD02096392
• UNSPSC Code: 12352203
• NACRES: NA.41

Propiedades

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: ~43 kDa
• species reactivity: rat, mouse, human
• concentration: 1 mg/mL
• technique(s): indirect immunofluorescence: 1:100-1:200; western blot: 1:500-1:1000
• isotype: IgG
• immunogen sequence: (K-A-SP-G-K)
• NCBI accession no.: NP_002040.1
• UniProt accession no.: P15976
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pSer310)
• Gene Information: human ... GATA1(2623)

Descripción

General description

GATA binding protein 1 (GATA1) is a key hematopoietic transcription factor. It is encoded by the gene mapped to human chromosome Xp11.23 and it belongs to the GATA transcription factor family.

Immunogen

Peptide sequence around phosphorylation site of serine 310 (K-A-S(p)-G-K), according to the protein GATA1.

Biochem/physiol Actions

GATA binding protein 1 (GATA1) plays a crucial role in erythroid and megakaryocyte differentiation and proliferation. It modulates the expression of genes and acts as an E-cadherin repressor. Mutations in the GATA1 gene have been linked to transient abnormal myelopoiesis (TAM) and myeloid leukemia of DS (ML-DS). The protein has anti-apoptotic functions in breast cancer.

Features and Benefits

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Target description

GATA1 encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable