SAB4200728

Anti-Chromogranin-A antibody, Mouse monoclonal

clone CHGA(419), purified from hybridoma cell culture

• Sinónimos: Anti-CHGA, Anti-CgA, Anti-Pituitary secretory protein I, Anti-SP-1
• Código UNSPSC: 41116158
• NACRES: NA.41

Propiedades

• origen biológico: mouse
• forma del anticuerpo: purified from hybridoma cell culture
• tipo de anticuerpo: primary antibodies
• clon: CHGA(419), monoclonal
• Formulario: buffered aqueous solution
• mol peso: ~50 kDa
• reactividad de especies: human
• concentración: ~1.0 mg/mL
• técnicas: immunoblotting: 10-20 μg/mL using human embryonic kidney 293T cell extract; immunohistochemistry: 10-20 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded Human Stomach sections
• isotipo: IgG1
• Nº de acceso UniProt: P10645
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... CHGA(1113)

Descripción

Descripción general

Anti-Chromogranin-A antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the CHGA(419) hybridoma produced by the fusion of mouse myeloma cells and splenocytes from a BALB/c mouse immunized with synthetic peptide corresponding to the C-terminal region of human Chromogranin-A protein, conjugated to KLH. Chromogranin-A protein, also known as CgA, pituitary secretory protein I (SP-1) is the major member of the granin family of acidic secretory glycoproteins that are expressed in all endocrine and neuroendocrine cells. The protein is in neuroendocrine cells distributed throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets and the secretory vesicles of neurons.

Inmunógeno

synthetic peptide corresponding to the C-terminal region of human Chromogranin-A protein conjugated to KLH

Aplicación

Anti-Chromogranin-A antibody has been used in immunohistochemistry,immunoblotting.

Acciones bioquímicas o fisiológicas

Chromogranin-A has a crucial intracellular role in secretory granule biogenesis and calcium homeostasis. Tissue-specific and context-specific proteolytic cleavage of Chromogranin-A yields polypeptides with paracrine and endocrine activity including: vasostatin, catestatin, GE25 and WE-14. Increased blood levels of Chromogranin-A have been shown in numerous inflammatory and non-inflammatory conditions, including neuroendocrine tumours (carcinoid tumors, phenochromocytomas, paragangliomas and others), renal failure, arterial hypertension, chronic heart failure and rheumatoid arthritis.

Forma física

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable