SAB4200242

Anti-MAN1C1 antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• Sinónimos: Anti-1,2-alpha-mannosidase IC, mannosyl-oligosaccharide 1,2-alpha-mannosidase IC, Anti-HMIC, Anti-MAN1A3, Anti-MAN1C, Anti-mannosidase, alpha, class 1C, member 1, Anti-pp6318, Anti-processing alpha-1,2-mannosidase IC
• UNSPSC Code: 12352203
• NACRES: NA.41

Propiedades

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: ~71 kDa
• species reactivity: rat, human
• concentration: ~1.0 mg/mL
• technique(s): western blot: 1-0.2 μg/mL using whole extracts of HEK-293 cells overexpressing human MAN1C1; western blot: 5-10 μg/mL using whole extracts of rat liver
• UniProt accession no.: Q9NR34
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... MAN1C1(57134) ; rat ... Man1c1(362625)

Descripción

General description

Mannosidase alpha class 1C member 1 (MAN1C1) is a member of the glycosyl hydrolase 47 family. MAN1C1 is a type II membrane protein with sequence similarity to class Iα,2-mannosidases, which localizes to the Golgi apparatus membrane.

Application

Anti-MAN1C1 antibody produced in rabbit has been used in immunoblotting.

Biochem/physiol Actions

Mannosidase alpha class 1C member 1 (MAN1C1) is involved in the maturation of Asn-linked oligosaccharides and quality control. It trims α-1,2-linked mannose residues from Glc₃Man₉GlcNA_c2 to produce the Man₅GlcNA_c2 processing intermediate. MAN1C1 overexpression accelerates endoplasmic reticulum-associated protein degradation (ERAD) of terminally misfolded human null Hong Kongα1-antitrypsin.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Storage Class: 10 - Combustible liquids
• flash_point_f: Not applicable
• flash_point_c: Not applicable