SAB4200160

Anti-Synaptotagmin 7 antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• Sinónimos: Anti-IPCA-7, Anti-PCANAP7, Anti-SYT-VII, Anti-SYT7
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• Formulario: buffered aqueous solution
• mol peso: ~45 kDa
• reactividad de especies: mouse, human
• validación mejorada: recombinant expression; Learn more about Antibody Enhanced Validation
• concentración: ~1.0 mg/mL
• técnicas: western blot: 1-2 μg/mL using mouse brain extracts (S1 fraction) and HEK-293T cell lysates expressing human synaptotagmin 7
• Nº de acceso UniProt: O43581
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• Información sobre el gen: human ... SYT7(9066) ; mouse ... Syt7(54525)

Descripción

Descripción general

Synaptotagmin 7, also known as Syt7, is a transmembrane Ca²⁺ binding protein. It belongs to synaptotagmin family of proteins. Syt7 contains a single transmembrane domain, a variable linker sequence and C2A and C2B Ca²⁺-binding domains. Syt7 is ubiquitously expressed during development but is later restricted to dividing cells, postmitotic neurons and neuroendocrine cells.

Aplicación

Anti-Synaptotagmin 7 antibody produced in rabbit has been used in immunoblotting.

Acciones bioquímicas o fisiológicas

Synaptotagmins regulates membrane or vesicular trafficking, including synaptic vesicle (SV) exocytosis. Synaptotagmin 7 plays a vital role in regulation of Ca²⁺-dependent lysosome exocytosis. Syt7 is expressed in pancreatic β-cells and has been suggested to function as a Ca²⁺ sensor regulating insulin secretion. Knockout of Syt7 in mice results in impaired insulin secretion and glucose intolerance.

Forma física

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable