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MilliporeSigma

SAB4200078

Sigma-Aldrich

Anti-Coronin-1A (N-terminal) antibody produced in rabbit

~1.5 mg/mL, affinity isolated antibody

Sinónimos:

Anti-CLABP, Anti-CLIPINA (coronin-like protein A), Anti-CORO1A, Anti-HCORO1, Anti-TACO (tryptophane aspartate-containing coat protein), Anti-p57

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~57 kDa

species reactivity

mouse, human, rat

concentration

~1.5 mg/mL

technique(s)

western blot: 1.5-3.0 μg/mL using Jurkat cell lysates, or lysates of mouse brain (S1 fraction) or rat spleen (S1 fraction)

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

General description

Coronin 1A (Coronin-1A) is encoded by the gene mapped to human chromosome 16p11.2. The encoded 57kDa protein, belongs to the coronin family and is mainly expressed in hematopoietic cells. Coronin family of proteins are characterized with a highly conserved N-terminal extension (NE), five canonical WD40 repeats, a C-terminal conserved extension (CE), followed by a unique region (U), and ends with a C-terminal coiled-coil (CC) domain.

Application

Anti-Coronin-1A (N-terminal) antibody produced in rabbit has been used in immunoblotting.

Biochem/physiol Actions

Coronin 1A (Coronin-1A) plays a vital role in F-actin stabilization in vitro. It is also involved in phagocytosis by neutrophils and macrophages and in T-cell receptor (TCR)-mediated activation of T lymphocytes. Additionally, it is also implicated in the regulation of activate actin-related protein-2/3 (Arp2/3)-dependent processes. Mutation in the gene has been observed in T cell-deficient, B cell- and natural killer (NK) cell-sufficient (T?B+NK+) severe combined immunodeficiency (SCID) patients.
Coronin-1A also plays a vital role in regulation of leukocyte specific signaling. In T-lymphocytes, coronin-1A facilitates the association of cytoskeleton dynamics to TCRαβ induced cell signaling, chemokine-mediated cell migration and homeostasis. Loss of coronin-1A gene expression in murine T cells leads to reduced ability to respond to chemotactic gradient and decrease in peripheral T cells due to apoptosis.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

Recurrent viral infections associated with a homozygous CORO1A mutation that disrupts oligomerization and cytoskeletal association.
Yee CS
The Journal of Allergy and Clinical Immunology, 137, 879-888 (2016)
The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency.
Shiow LR
Nature Immunology, 9, 1307-1315 (2008)
Christina S Yee et al.
The Journal of allergy and clinical immunology, 137(3), 879-888 (2015-10-20)
Coronin-1A (CORO1A) is a regulator of actin dynamics important for T-cell homeostasis. CORO1A deficiency causes T(-)B(+) natural killer-positive severe combined immunodeficiency or T-cell lymphopenia with severe viral infections. However, because all known human mutations in CORO1A abrogate protein expression, the
Coronin-1A Stabilizes F-Actin by Bridging Adjacent Actin Protomers and Stapling Opposite Strands of the Actin Filament
Galkin VE
Journal of Molecular Biology, 376, 607-613 (2008)
The actin regulator coronin-1A is mutated in a thymic egress deficient mouse strain and in a T?B+NK+ SCID patient
Shiow L R
Nature Immunology, 9, 1307?1315-1307?1315 (2008)

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