SAB4200028

Anti-XRN1 antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

• Sinónimos: Anti-5′-3′ exoribonuclease 1, Anti-DKFZp434P0721, Anti-DKFZp686B22225, Anti-DKFZp686F19113, Anti-FLJ41903
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• Formulario: buffered aqueous solution
• mol peso: antigen ~195 kDa
• reactividad de especies: mouse, human
• concentración: ~1.0 mg/mL
• técnicas: indirect immunofluorescence: 2-5 μg/mL using paraformaldehyde fixed NIH-3T3 cells; western blot: 2-4 μg/mL using nuclear extract of HEK-293T
• Nº de acceso UniProt: Q8IZH2
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... XRN1(54464) ; mouse ... Xrn1(24127) ; rat ... Xrn1(300944)

Descripción

Descripción general

5→3′ exoribonuclease 1 (XRN1) is a cytoplasmic enzyme, encoded by the gene mapped to human chromosome 3q23. The encoded protein has a molecular mass of 175kDa and is a member of XRN family of exoribonucleases. It is mainly localized in cytoplasmic P- bodies.

Aplicación

Anti-XRN1 antibody produced in rabbit has been used in:

• immunostaining
• immunoblotting
• immunofluorescence.

Acciones bioquímicas o fisiológicas

5→3′ exoribonuclease 1 (XRN1) catalyzes the degradation of decapped (5′ monophosphorylated) RNA in the 5′→3′ direction. In addition, it also degrades tRNA (iMet) that is distributed in the cytoplasm. XRN1 is implicated in the modulation of dsRNA accumulation and dsRNA-responsive innate immune effectors. The encoded protein also plays an essential role in maintaining the fidelity of cellular RNA turnover in eukaryotes. XRN1 is required for proper bone formation in humans. Therefore, mutation in the gene leads to development of osteosarcoma.

Forma física

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable