NLR family CARD domain containing 3 (NLRC3), also referred to as nucleotide-binding oligomerization domain containing 3 (NOD3), is encoded by the gene mapped to human chromosome 16p13.3. The encoded protein belongs to the NLR protein family and is abundantly expressed in purified T cells, B cells and natural killer (NK) cells, but also in thymus, uterus and kidney.
Immunogen
NOD3 antibody was raised against an 18 amino acid peptide near the center of human NOD3.
Biochem/physiol Actions
NLR family CARD domain containing 3 (NLRC3) negatively regulates nuclear factor-κB (NF-κB) activity and innate immune signaling induced by the DNA sensor STING (stimulator of interferon gene). NLRC3 inhibits mammalian target of rapamycin (mTOR) pathways involved in providing protection against colorectal cancer. Thus, downregulated expression of the gene has been observed in colorectal cancer and Wegener′s granulomatosis patients.
Features and Benefits
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Linkage
The action of this antibody can be blocked using blocking peptide SBP3500544.
Physical form
Supplied in PBS with 0.02% sodium azide.
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Expression profile of innate immune receptors, NLRs and AIM2, in human colorectal cancer: correlation with cancer stages and inflammasome components
Liu R, et al.
Oncotarget, 6(32), 33456-33456 (2015)
NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING
Zhang L, et al.
Immunity, 40(3), 329-341 (2014)
NLR proteins: integral members of innate immunity and mediators of inflammatory diseases
Wilmanski, et al.
Journal of Leukocyte Biology, 83(1), 13-30 (2008)
NLRC3 is an inhibitory sensor of PI3K?mTOR pathways in cancer
Karki R, et al.
Nature, 540(7634), 583-583 (2016)
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