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Key Documents

Certificado de origen (COO)/COA

SAB1401419

Anti-MKKS antibody produced in rabbit

Name: Anti-MKKS antibody produced in rabbit
Brand: SIGMA

purified immunoglobulin, buffered aqueous solution

Sinónimos:

BBS6, HMCS, KMS, MKS

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

western blot: 1 μg/mL

NCBI accession no.

NM_018848.2

UniProt accession no.

Q9NPJ1

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MKKS(8195)

General description

McKusick-Kaufman syndrome putative chaperonin (MKKS) is a centrosome-shuttling protein.The gene is located on human chromosome 20p12.2.It This protein encodes a chaperon-like protein.

Immunogen

MKKS (NP_061336.1, 1 a.a. ~ 570 a.a) full-length human protein.

Sequence
MSRLEAKKPSLCKSEPLTTERVRTTLSVLKRIVTSCYGPSGRLKQLHNGFGGYVCTTSQSSALLSHLLVTHPILKILTASIQNHVSSFSDCGLFTAILCCNLIENVQRLGLTPTTVIRLNKHLLSLCISYLKSETCGCRIPVDFSSTQILLCLVRSILTSKPACMLTRKETEHVSALILRAFLLTIPENAEGHIILGKSLIVPLKGQRVIDSTVLPGILIEMSEVQLMRLLPIKKSTALKVALFCTTLSGDTSDTGEGTVVVSYGVSLENAVLDQLLNLGRQLISDHVDLVLCQKVIHPSLKQFLNMHRIIAIDRIGVTLMEPLTKMTGTQPIGSLGSICPNSYGSVKDVCTAKFGSKHFFHLIPNEATICSLLLCNRNDTAWDELKLTCQTALHVLQLTLKEPWALLGGGCTETHLAAYIRHKTHNDPESILKDDECTQTELQLIAEAFCSALESVVGSLEHDGGEILTDMKYGHLWSVQADSPCVANWPDLLSQCGCGLYNSQEELNWSFLRSTRRPFVPQSCLPHEAVGSASNLTLDCLTAKLSGLQVAVETANLILDLSYVIEDKN

Biochem/physiol Actions

McKusick-Kaufman syndrome putative chaperonin (MKKS) plays a crucial role in cytokinesis.

Physical form

Solution in phosphate buffered saline, pH 7.4

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

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Molecular diagnosis reveals genetic heterogeneity for the overlapping MKKS and BBS phenotypes

Schaefer, et al.

European Journal of Medical Genetics, 54(2), 157-160 (2011)

MKKS is a centrosome-shuttling protein degraded by disease-causing mutations via CHIP-mediated ubiquitination

Hirayama , et al.

Molecular Biology of the Cell, 19(3), 899-911 (2008)

MKKS/BBS6, a divergent chaperonin-like protein linked to the obesity disorder Bardet-Biedl syndrome, is a novel centrosomal component required for cytokinesis

Kim, Jun, et al.

Journal of Cell Science, 118(5), 1007-1020 (2005)

Genes and mutations causing retinitis pigmentosa.

S P Daiger et al.

Clinical genetics, 84(2), 132-141 (2013-05-25)

Retinitis pigmentosa (RP) is a heterogeneous set of inherited retinopathies with many disease-causing genes, many known mutations, and highly varied clinical consequences. Progress in finding treatments is dependent on determining the genes and mutations causing these diseases, which includes both

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