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S6256

Sulfamethazine

99.0-101.0% (on dried basis)

Sinónimos:

4,6-Dimethylsulfadiazine, 4-Amino-N-(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide, Sulfadimethyldiazine, Sulfadimidine

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A ustedes/SKUDisponibilidadPrecio
25 g

Disponible para enviar HOYdesdeMILWAUKEE

$60.30
100 g

Disponible para enviar HOYdesdeMILWAUKEE

$105.00
$89.25

Acerca de este artículo

Fórmula empírica (notación de Hill):
C12H14N4O2S
Número CAS:
Peso molecular:
278.33
UNSPSC Code:
51284910
NACRES:
NA.85
PubChem Substance ID:
EC Number:
200-346-4
Beilstein/REAXYS Number:
261304
MDL number:

$60.30


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Quality Segment

assay

99.0-101.0% (on dried basis)

form

powder or crystals

storage condition

(Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)

color

white to off-white

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

DNA synthesis | interferes, enzyme | inhibits

storage temp.

2-8°C

SMILES string

Cc1cc(C)nc(NS(=O)(=O)c2ccc(N)cc2)n1

InChI

1S/C12H14N4O2S/c1-8-7-9(2)15-12(14-8)16-19(17,18)11-5-3-10(13)4-6-11/h3-7H,13H2,1-2H3,(H,14,15,16)

InChI key

ASWVTGNCAZCNNR-UHFFFAOYSA-N

General description

Chemical structure: sulfonamide

Application

Sulfamethazine is an antibiotic used to treat bronchitis, prostatitis and urinary tract infections[1]. It is used in disposition and depletion kinetic studies[2][3]. It is used to develop detection techniques for quantification in fluids such as cows′ milk, honey and swine urine[4].

Biochem/physiol Actions

An antimicrobial sulfur drug. Induces CYP3A4 expression and acetylated by N-acetyltransferase. Exhibits sex dependent pharmacokinetics, metabolized by the male specific isoform CYP2C11.
Sulfamethazine is an antimicrobial sulfur drug that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfamethazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid[1]. It induces CYP3A4 expression and is acetylated by N-acetyltransferase. It exhibits sex dependent pharmacokinetics, metabolized by the male specific isoform CYP2C11. Sulfamethazine is bacteriostatic.

Packaging

25G,100G

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

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Este artículo
468021629000PHR3136
mode of action

DNA synthesis | interferes, enzyme | inhibits

mode of action

DNA synthesis | interferes, enzyme | inhibits

mode of action

-

mode of action

-

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

antibiotic activity spectrum

-

antibiotic activity spectrum

-

Quality Level

200

Quality Level

200

Quality Level

-

Quality Level

300

assay

99.0-101.0% (on dried basis)

assay

-

assay

-

assay

-

form

powder or crystals

form

-

form

-

form

-

storage temp.

2-8°C

storage temp.

-

storage temp.

-

storage temp.

2-8°C


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Clase de almacenamiento

11 - Combustible Solids

ppe

Eyeshields, Gloves, type N95 (US)

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Skin Irrit. 2

flash_point_f

Not applicable

flash_point_c

Not applicable



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Questions

  1. Is Sulfamethazine (Product code: S6256) soluble in water of in any specific solvent. Please suggest.

    1 answer
    1. This product is slightly soluble in water at < 1mg/mL. Other solvents include DMSO, DMF, and Acetone at approximately 50 mg/mL.

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