S4139
Spermidine
BioReagent, suitable for cell culture
Sinónimos:
1,8-Diamino-4-azaoctane, N-(3-Aminopropyl)-1,4-diaminobutane
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About This Item
Fórmula lineal:
NH2(CH2)3NH(CH2)4NH2
Número de CAS:
Peso molecular:
145.25
Beilstein:
1698591
Número CE:
Número MDL:
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
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Línea del producto
BioReagent
Ensayo
≥98% (GC)
Formulario
solid
técnicas
cell culture | mammalian: suitable
color
clear colorless to light yellow-white
índice de refracción
n20/D 1.479 (lit.)
densidad
0.925 g/mL at 25 °C (lit.)
temp. de almacenamiento
2-8°C
cadena SMILES
NCCCCNCCCN
InChI
1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2
Clave InChI
ATHGHQPFGPMSJY-UHFFFAOYSA-N
Información sobre el gen
rat ... Ppm1a(24666)
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Acciones bioquímicas o fisiológicas
Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; Stimulates T4 polynucleotide kinase activity.
Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T4 polynucleotide kinase activity.
Spermidine together with putrescine and spermine compose a family of biogenic polyamines (polycations) that are required for the survival of the vast majority of living cells. Polyamines interact with negatively charged molecules such as proteoglycan, glycated proteins and nucleic acids (DNA and RNA). Biogenic polyamines are found to modulate protein synthesis at different levels. This effect may be explained by the ability of polyamines to bind and influence the secondary structure of tRNA, mRNA, and rRNA. Spermine also helps stabilize nucleic acid helical structure and the conformation of glycated proteins such as the histones. Spermine and spermidine are components of various nucleic acid transfection protocols. Spermidine Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T4 polynucleotide kinase activity.
Spermidine is biogenic polyamine formed from putrescine, a precursor of spermine. It was first detected in human sperm, but occurs widely in nature. It is essential in both normal and neoplastic tissue growth. Spermidine has a role in cell growth processes and the formation and interconversion of spermidine in mammalian cells has been reported. It has been studied in the regulation of tRNA methyltransferase activity and stimulates T4 polynucleotide kinase activity.
Spermidine is biogenic polyamine formed from putrescine, a precursor of spermine. It was first detected in human sperm, but occurs widely in nature. It is essential in both normal and neoplastic tissue growth. Spermidine has a role in cell growth processes and the formation and interconversion of spermidine in mammalian cells has been reported. It has been studied in the regulation of tRNA methyltransferase activity and stimulates T4 polynucleotide kinase activity.
Precaución
Solutions should be sterile-filtered, not autoclaved, if sterile solution is necessary. Spermidine deaminates with time; solutions should be stored frozen. Prepare new solutions frequently.
Producto relacionado
Referencia del producto
Descripción
Precios
Palabra de señalización
Danger
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Skin Corr. 1B
Código de clase de almacenamiento
8A - Combustible corrosive hazardous materials
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
233.6 °F - closed cup
Punto de inflamabilidad (°C)
112 °C - closed cup
Equipo de protección personal
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
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The biochemistry and biological function of the naturally occurring polyamines, putrescine, spermidine, and spermine, have been reviewed with special reference to animal organisms. These compounds are universally distributed in all living material. Their biosynthesis from ornithine and methionine is accurately
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