This product should be stored in 2-8°C in powdered format. The solution can be stored at 2-8°C for several weeks or at -20°C for more extended periods.
S4014
Spectinomycin dihydrochloride pentahydrate
powder, suitable for cell culture and plant cell culture, BioReagent
Sinónimos:
Spectinomycin
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5 G
$135.00
25 G
$546.00
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5 G
$135.00
25 G
$546.00
About This Item
Fórmula empírica (notación de Hill):
C14H24N2O7 · 2HCl · 5H2O
Número de CAS:
Peso molecular:
495.35
Número CE:
Número MDL:
Código UNSPSC:
12352207
ID de la sustancia en PubChem:
NACRES:
NA.76
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Nombre del producto
Spectinomycin dihydrochloride pentahydrate, powder, BioReagent, suitable for cell culture
origen biológico
synthetic (inorganic)
Nivel de calidad
Línea del producto
BioReagent
Formulario
powder
potencia
≥603 μg per mg
condiciones de almacenamiento
(Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)
técnicas
cell culture | mammalian: suitable
cell culture | plant: suitable
impurezas
endotoxin, tested
color
white to pale buff
solubilidad
H2O: soluble 50 mg/mL at
espectro de actividad antibiótica
Gram-negative bacteria
Gram-positive bacteria
aplicaciones
agriculture
Modo de acción
protein synthesis | interferes
temp. de almacenamiento
2-8°C
cadena SMILES
O.O.O.O.O.Cl.Cl.CN[C@@H]1[C@H](O)[C@H](NC)[C@H]2O[C@]3(O)[C@@H](O[C@H](C)CC3=O)O[C@@H]2[C@H]1O
InChI
1S/C14H24N2O7.2ClH.5H2O/c1-5-4-6(17)14(20)13(21-5)22-12-10(19)7(15-2)9(18)8(16-3)11(12)23-14;;;;;;;/h5,7-13,15-16,18-20H,4H2,1-3H3;2*1H;5*1H2/t5-,7-,8+,9+,10+,11-,12-,13+,14+;;;;;;;/m1......./s1
Clave InChI
DCHJOVNPPSBWHK-UXXUFHFZSA-N
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Descripción general
Chemical structure: aminoglycoside
Spectinomycin has generally been used for the treatment of gonorrhea in males, and a study conducted shows that spectinomycin dihydrochloride pentahydrate provides effective treatment against gonorrhea as well.[1] Clinically, spectinomycin dihydrochloride pentahydrate is easier to use in injections as it shows higher solubility than spectinomycin.[2]
Aplicación
Spectinomycin dihydrochloride pentahydrate has been used as a supplement in different types of media.[3][4]
Spectinomycin is an aminocyclitol antibiotic derived from Streptomyces spectabilis. It has been shown to have a wide variety of uses, including treating acute gonorrheal urethritis and cervictis, to mark cell layers to monitor cell fate during leaf development, as a selection marker in plant related transformation systems for plant cells containing the marker gene Spcr, to study respiratory tract infections of cattle caused by Pasteurella multocida and Mannheimia haemolytica, and to generate plants deficient for the plastid-encoded RNA polymerase on MS-agar media. Spectinomycin also has use in amplification of low copy number plasmid carrying replicons. It is recommended for use in cell culture applications at 7.5-20 mg/L.
Acciones bioquímicas o fisiológicas
Mode of Action: Spectinomycin acts by inhibiting protein synthesis and elongation by binding to the bacterial 30S ribosomal subunit and interfering with peptidyl tRNA translocation.
Mode of Resistance: A mutation in rpsE, the gene for ribosomal protein S5, prevents the binding of spectinomycin. Resistance is also conferred by the aminoglycoside-3′-adenyltransferase gene (aadA).
Antimicrobial spectrum: Spectinomycin acts against gram-negative and gram-positive bacteria.
Mode of Resistance: A mutation in rpsE, the gene for ribosomal protein S5, prevents the binding of spectinomycin. Resistance is also conferred by the aminoglycoside-3′-adenyltransferase gene (aadA).
Antimicrobial spectrum: Spectinomycin acts against gram-negative and gram-positive bacteria.
Precaución
Solutions can be stored at 2-8°C for several weeks or at -20°C for more extended periods.
Nota de preparación
Stock solutions should be prepared at 10 mg/mL in water and filter sterilized.
Otras notas
Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.
Palabra de señalización
Warning
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Órganos de actuación
Respiratory system
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 2
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
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Los clientes también vieron
Spectinomycin: minimum inhibitory concentrations for Neisseria gonorrhoeae.
I A Porter et al.
The British journal of venereal diseases, 50(4), 289-290 (1974-08-01)
Aditya C Bandekar et al.
Current biology : CB, 30(20), 3961-3971 (2020-09-12)
Although the major events in prokaryotic cell cycle progression are likely to be coordinated with transcriptional and metabolic changes, these processes remain poorly characterized. Unlike many rapidly growing bacteria, DNA replication and cell division are temporally resolved in mycobacteria, making
Spectinomycin dihydrochloride in the treatment of gonorrhoea in males.
R R Willcox
The British journal of clinical practice, 29(2), 34-36 (1975-02-01)
Songul Gurel et al.
Methods in molecular biology (Clifton, N.J.), 847, 109-122 (2012-02-22)
Successful efforts describing in vitro culturing, regeneration, and transformation of grain sorghum were reported, using particle bombardment, as early as 1993, and with Agrobacterium tumefaciens in 2000. Reported transformation efficiencies via Agrobacterium routinely range from 1 to 2%. Recently, such
Robert A Seaborne et al.
The Journal of physiology, 597(14), 3727-3749 (2019-05-17)
We have recently identified that a HECT domain E3 ubiquitin ligase, named UBR5, is altered epigenetically (via DNA methylation) after human skeletal muscle hypertrophy, where its gene expression is positively correlated with increasing lean leg mass after training and retraining.
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