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S1014

Streptonigrin

from Streptomyces flocculus, ≥98% (HPLC), powder, apoptosis inducer

Sinónimos:

Bruneomycin, Nigrin

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Tamaño de envaseSKUDisponibilidadPrecio
1 mg

Envío estimado HOYdesdeMILWAUKEE

$130.00
5 mg
Comprobar disponibilidad del carrito
$476.00

Acerca de este artículo

Fórmula empírica (notación de Hill):
C25H22N4O8
Número CAS:
3930-19-6
Peso molecular:
506.46
NACRES:
NA.77
PubChem Substance ID:
24899458
UNSPSC Code:
12352200
EC Number:
223-501-8
MDL number:
MFCD00063401
Beilstein/REAXYS Number:
599390
Assay:
≥98%
Quality level:
200

$130.00

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Nombre del producto

Streptonigrin from Streptomyces flocculus, ≥98%

Quality Level

200

assay

≥98%

antibiotic activity spectrum

viruses

mode of action

DNA synthesis | interferes

storage temp.

2-8°C

SMILES string

COc1ccc(c(O)c1OC)-c2c(C)c(nc(c2N)-c3ccc4C(=O)C(OC)=C(N)C(=O)c4n3)C(O)=O

InChI

1S/C25H22N4O8/c1-9-14(10-6-8-13(35-2)23(36-3)20(10)30)15(26)19(29-17(9)25(33)34)12-7-5-11-18(28-12)22(32)16(27)24(37-4)21(11)31/h5-8,30H,26-27H2,1-4H3,(H,33,34)

InChI key

PVYJZLYGTZKPJE-UHFFFAOYSA-N

Biochem/physiol Actions

Streptonigrin (SN) is an aminoquinone antitumour antibiotic. Its antineoplastic activity requires reductive activation by Xanthine-converting enzymes. It induces apoptosis by a mechanism involving NF-κB. DNA cleavage reaction and chromosome damage by SN are influenced by the nature of the metal ion present and dependent on the production of free radicals. Its antibiotic activity is iron-activated.

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Este artículo
N9162A9789S5921
Streptonigrin from Streptomyces flocculus ≥98%

Sigma-Aldrich

S1014

Streptonigrin from Streptomyces flocculus

Neocarzinostatin from Streptomyces carzinostaticus ≥90% (SDS-PAGE), ~0.5 mg/mL

Sigma-Aldrich

N9162

Neocarzinostatin from Streptomyces carzinostaticus

Anisomycin from Streptomyces griseolus ≥98% (HPLC), solid

Sigma-Aldrich

A9789

Anisomycin from Streptomyces griseolus

Staurosporine from Streptomyces sp. Molecular Biology, ≥95% (HPLC)

Sigma-Aldrich

S5921

Staurosporine from Streptomyces sp.

assay

≥98%

assay

≥90% (SDS-PAGE)

assay

≥98% (HPLC)

assay

≥95% (HPLC)

Quality Level

200

Quality Level

200

Quality Level

300

Quality Level

300

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

antibiotic activity spectrum

viruses

antibiotic activity spectrum

neoplastics

antibiotic activity spectrum

neoplastics

antibiotic activity spectrum

fungi

mode of action

DNA synthesis | interferes

mode of action

DNA synthesis | interferes

mode of action

protein synthesis | interferes

mode of action

enzyme | inhibits

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H300

Hazard Classifications

Acute Tox. 1 Oral

Clase de almacenamiento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificados de análisis (COA)

Lot/Batch Number
0000510642
0000548686
0000548685
0000525179
0000548686

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Laura C C Cook et al.
mBio, 10(3) (2019-06-27)
Streptococcus pyogenes (group A streptococcus [GAS]) is a serious human pathogen with the ability to colonize mucosal surfaces such as the nasopharynx and vaginal tract, often leading to infections such as pharyngitis and vulvovaginitis. We present genome-wide transcriptome sequencing (RNASeq)
Mi Huang et al.
Veterinary research, 52(1), 48-48 (2021-03-21)
Iron is essential for most bacteria to survive, but excessive iron leads to damage by the Fenton reaction. Therefore, the concentration of intracellular free iron must be strictly controlled in bacteria. Riemerella anatipestifer (R. anatipestifer), a Gram-negative bacterium, encodes the
Nilanjana Chatterjee et al.
Journal of bacteriology, 202(14) (2020-05-13)
Group A streptococcus (GAS) produces millions of infections worldwide, including mild mucosal infections, postinfection sequelae, and life-threatening invasive diseases. During infection, GAS readily acquires nutritional iron from host heme and hemoproteins. Here, we identified a new heme importer, named SiaFGH
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Número de artículo de comercio global

SKUGTIN
S1014-1MG04061836844714
S1014-5MG04061836846343

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