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S1013

Sigma-Aldrich

(−)-Scopolamine hydrochloride

≥90% (HPLC), powder

Sinónimos:

Hyoscine hydrochloride, Scopine tropate

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About This Item

Fórmula empírica (notación de Hill):
C17H21NO4 · HCl
Número de CAS:
55-16-3
Peso molecular:
339.81
Beilstein/REAXYS Number:
4168778
EC Number:
200-225-6
MDL number:
MFCD00058096
UNSPSC Code:
12352200
PubChem Substance ID:
24899457

assay

≥90% (HPLC)

form

powder

optical activity

[α]25/D ~−27°, c = 1 in H2O(lit.)

color

white

solubility

H2O: 50 mg/mL

SMILES string

Cl.[H][C@]12C[C@H](C[C@]([H])(N1C)[C@]3([H])O[C@]23[H])OC(=O)[C@H](CO)c4ccccc4

InChI

1S/C17H21NO4.ClH/c1-18-13-7-11(8-14(18)16-15(13)22-16)21-17(20)12(9-19)10-5-3-2-4-6-10;/h2-6,11-16,19H,7-9H2,1H3;1H/t11-,12-,13-,14+,15-,16+;/m1./s1

InChI key

KXPXJGYSEPEXMF-MOUKNHLCSA-N

Gene Information

human ... CHRM1(1128)

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Biochem/physiol Actions

Competitive nonselective muscarinic acetylcholine antagonist. Scopolamine-induced amnesia in laboratory animals is a commonly-used model of memory deficit.

Caution

The powder is stable at least four years stored at room temperature.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

pictograms

Skull and crossbonesCorrosion
GHS06,GHS05

signalword

Danger

Hazard Classifications

Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Eye Dam. 1 - Skin Sens. 1

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

flash_point_f

170.6 °F - closed cup

flash_point_c

77 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Stacey J Sukoff Rizzo et al.
Current protocols in mouse biology, 8(2), e45-e45 (2018-06-21)
The relationship between chronological age (lifespan) and biological age (healthspan) varies amongst individuals. Understanding the normal trajectory and characteristic traits of aging mice throughout their lifespan is important for selecting the most reliable and reproducible measures to test hypotheses. The
Sunjoo Joo et al.
Nature communications, 13(1), 1133-1133 (2022-03-05)
Most sexual organisms inherit organelles from one parent, commonly by excluding organelles from the smaller gametes. However, post-mating elimination of organelles derived from one gamete ensures uniparental inheritance, where the underlying mechanisms to distinguish organelles by their origin remain obscure.
X Bian et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 21(9), 969-977 (2009-04-21)
Neuromuscular transmission is crucial for normal gut motility but little is known about its postnatal maturation. This study investigated excitatory/inhibitory neuromuscular transmission in vitro using ileal nerve-muscle preparations made from neonatal (< or =48 h postnatal) and adult ( approximately
Fang-Fang Chen et al.
Oncoimmunology, 9(1), 1831153-1831153 (2020-10-29)
Therapeutic monoclonal antibodies against the PD-L1/PD-1 (programmed death ligand-1/programmed cell death protein-1) axis have achieved great successes in cancer treatments, but the development of small-molecule immunomodulators of the pathway has lagged far behind. We established a cellular coculture assay with
Narayana Krishna Yelleswarapu et al.
Neurogastroenterology and motility, 34(12), e14439-e14439 (2022-12-03)
Alterations in gastrointestinal (GI) function and the gut-brain axis are associated with progression and pathology of Alzheimer's Disease (AD). Studies in AD animal models show that changes in the gut microbiome and inflammatory markers can contribute to AD development in
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