R2029
Monoclonal Anti-Rapsyn antibody produced in mouse
1 mg/mL, clone 1234, purified immunoglobulin, buffered aqueous solution
Sinónimos:
Anti-CMS11, Anti-CMS4C, Anti-FADS, Anti-FADS2, Anti-RAPSYN, Anti-RNF205
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About This Item
Productos recomendados
origen biológico
mouse
Nivel de calidad
conjugado
unconjugated
forma del anticuerpo
purified immunoglobulin
tipo de anticuerpo
primary antibodies
clon
1234, monoclonal
Formulario
buffered aqueous solution
reactividad de especies
amphibian, chicken, mouse, rat, fish
concentración
1 mg/mL
técnicas
western blot: 0.5 μg/mL using Torpedo californica electrocyte cell extracts
isotipo
IgG1
Nº de acceso UniProt
Condiciones de envío
dry ice
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
mouse ... Rapsn(19400)
rat ... Rapsn(362161)
Categorías relacionadas
Descripción general
The receptor-associated protein of the synapse (RAPSYN) is a peripheral membrane protein located in the skeletal muscles. It is co-localized along with nicotinic acetylcholine receptors (nAChRs) at the postsynaptic membrane due to the influence of neural agrin. Rapsyn consists of a myristoylated N-terminal, seven putative tetratricopeptide repeats, a coiled-coil domain, the RING-H2 domain, and the consensus sequence for phosphorylation.
Inmunógeno
whole purified rapsyn from Torpedo californica electric organ postsynaptic membrane.
Aplicación
Monoclonal Anti-Rapsyn antibody produced in mouse has been used in western blotting (0.5 μg/ml ) and immunocytochemistry (1:200).
Acciones bioquímicas o fisiológicas
The receptor-associated protein of the synapse (RAPSYN) participates in assembling the structure of the nicotinic postsynaptic membrane. It is required for the functioning of the neuromuscular junction. Mutations in the RAPSN gene are associated with endplate acetylcholine-receptor deficiency and Myasthenic syndrome.
Forma física
Solution in phosphate buffered saline containing 1.0 mg/mL BSA and 0.05% sodium azide.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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M K Ramarao et al.
The Journal of biological chemistry, 276(10), 7475-7483 (2000-11-23)
Rapsyn, a 43-kDa peripheral membrane protein of skeletal muscle, is essential for clustering nicotinic acetylcholine receptors (nAChR) in the postsynaptic membrane. Previous studies with rapsyn NH(2)-terminal fragments fused to green fluorescent protein, expressed in 293T cells along with nAChRs, establish
Rapsyn mutations in humans cause endplate acetylcholine-receptor deficiency and myasthenic syndrome.
Kinji Ohno et al.
American journal of human genetics, 70(4), 875-885 (2002-01-16)
Congenital myasthenic syndromes (CMSs) stem from genetic defects in endplate (EP)-specific presynaptic, synaptic, and postsynaptic proteins. The postsynaptic CMSs identified to date stem from a deficiency or kinetic abnormality of the acetylcholine receptor (AChR). All CMSs with a kinetic abnormality
M Bartoli et al.
The Journal of biological chemistry, 276(27), 24911-24917 (2001-05-09)
Rapsyn, a peripheral membrane protein of skeletal muscle, is necessary for the formation of the highly organized structure of the vertebrate neuromuscular junction. For mice lacking rapsyn, there is a failure of postsynaptic specialization characterized by an absence of nicotinic
Marianna Rodova et al.
Molecular and cellular biology, 24(16), 7188-7196 (2004-07-30)
Rapsyn is a synapse-specific protein that is required for clustering acetylcholine receptors at the neuromuscular junction. Analysis of the rapsyn promoter revealed a consensus site for the transcription factor Kaiso within a region that is mutated in a subset of
Benoît Zuber et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(26), 10622-10627 (2013-06-12)
The scaffolding protein at the neuromuscular junction, rapsyn, enables clustering of nicotinic acetylcholine receptors in high concentration and is critical for muscle function. Patients with insufficient receptor clustering suffer from muscle weakness. However, the detailed organization of the receptor-rapsyn network
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