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P7443

Sigma-Aldrich

L-α-fosfatidilcolina

from soybean, ≥99% (TLC), lyophilized powder

Sinónimos:

1,2-Diacil-sn-glicero-3-fosfocolina, 3-sn-Fosfatidilcolina, L-α-lecitina, Azolectina, PC

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100 MG
$149.00
500 MG
$473.00
1 G
$736.10

$149.00

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100 MG
$149.00
500 MG
$473.00
1 G
$736.10

About This Item

Número de CAS:
8002-43-5
Beilstein/REAXYS Number:
5209585
EC Number:
232-307-2
UNSPSC Code:
12352211
NACRES:
NA.25

$149.00

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biological source

soybean

Quality Level

200

assay

≥99% (TLC)

form

lyophilized powder

functional group

phospholipid

lipid type

phosphoglycerides

shipped in

ambient

storage temp.

−20°C

SMILES string

[P](=O)([O-])(OC[C@H](OC(=O)CCCCCCC\C=C/C\C=C/CCCCC)COC(=O)CCCCCCCCCCCCCCC)OCC[N+](C)(C)C

InChI

1S/C42H80NO8P/c1-6-8-10-12-14-16-18-20-21-23-25-27-29-31-33-35-42(45)51-40(39-50-52(46,47)49-37-36-43(3,4)5)38-48-41(44)34-32-30-28-26-24-22-19-17-15-13-11-9-7-2/h14,16,20-21,40H,6-13,15,17-19,22-39H2,1-5H3/b16-14-,21-20-/t40-/m1/s1

InChI key

JLPULHDHAOZNQI-ZTIMHPMXSA-N

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General description

L-α-Phosphatidylcholine (PC) is an asymmetric molecule with glycerol backbone and occurs naturally in lecithin of egg yolk.[1] It is a phospholipid and major choline source in mammalian cells. It is crucial for very low-density lipoprotein secretion in hepatocytes.[2] It is essential for the acetylcholine synthesis functions to nourish the brain.[1] PC plays a crucial role in lipid and lipoprotein metabolism. Deficiencies of enzymes in PC biosynthetic pathway leads to an array of metabolic disorder. Intracellular levels of hepatic PC to phosphatidylethanolamine (PE) ratio contributes to pathophysiology non-alcoholic fatty liver disease (NAFLD).[3] It has anti-inflammatory functionality and is effective in treating inflammatory bowel disease.[4] PC administration therapy is effective for treating benign symmetric lipomatosis.[5]

Application

L-α-Phosphatidylcholine has been used:
  • for liposome preparation[6]
  • as a component of stabilizer solution for preparing dispersed curcuminoid submicron particle (CSP)[7]
  • as a component of serum free substitute for whole blood cells[8]

Biochem/physiol Actions

Un fosfolípido estructural principal del cerebro, que constituye aproximadamente el 15% de los lípidos totales; localizado principalmente en la materia gris.

Packaging

Packaged under Argon

Preparation Note

Prepared by a modification of the procedure of Singleton, W.S., et al., J. Am. Oil Chem. Soc., 42, 53 (1965).

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
0000407637
0000395057
0000386774
SLCM7956
0000372879

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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Christopher B Lee et al.
Plant physiology, 149(2), 791-802 (2008-12-23)
As pollen tubes grow toward the ovary, they are in constant contact with the pistil extracellular matrix (ECM). ECM components are taken up during growth, and some pistil molecules exert their effect inside the pollen tube. For instance, the Nicotiana
Evaluation of the ability of arsenic species to traverse cell membranes by simple diffusion using octanol-water and liposome-water partition coefficients
Chavez-Capilla T, et al.
Journal of environmental sciences (China), 49, 222-232 (2016)
Curcuminoid submicron particle ameliorates cognitive deficits and decreases amyloid pathology in Alzheimer?s disease mouse model
Tai YH, et al.
Oncotarget, 9(12), 10681-10681 (2018)
Mesotherapy for benign symmetric lipomatosis
Hasegawa T, et al.
Aesthetic Plastic Surgery, 34(2), 153-156 (2010)
PERIPHERAL BLOOD PROGENITOR CELLS-Storage of unprocessed G-CSF-mobilized whole blood in a modified Leibovitz's L15 medium preserves clonogenic capacity for at least 7 days
Kreuk AM de, et al.
Bone Marrow Transplantation, 28(2), 145-156 (2001)
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Questions

1–2 of 2 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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