Soluble at 50mg/ml, it can be dissolved in water, but it is recommended to use saline, NaCl, DPBS, Hanks, or culture medium. Please note that a reference in peer- reviewed papers at sial.com isolated glomerular endothelial cells at 0.1% in DMEM. This paper may also be of reference "Differential expression of type IV collagen isoforms in rat glomerular endothelial and mesangial cells (https://www.sciencedirect.com/science/article/pii/S0006291X02006939?via%3Dihub)
P5515
Prostaglandin E1
≥98% (HPLC), powder, vasodilator
Sinónimos:
(11α,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-enoic acid, Alprostadil, PGE1
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1 MG
$150.00
5 MG
$568.00
10 MG
$693.00
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1 MG
$150.00
5 MG
$568.00
10 MG
$693.00
About This Item
Fórmula empírica (notación de Hill):
C20H34O5
Número de CAS:
Peso molecular:
354.48
Beilstein:
5294062
Número CE:
Número MDL:
Código UNSPSC:
12352211
eCl@ss:
42020658
ID de la sustancia en PubChem:
NACRES:
NA.77
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Nombre del producto
Prostaglandin E1, ≥98% (HPLC), synthetic
origen biológico
synthetic
Ensayo
≥98% (HPLC)
Formulario
(powder to crystals)
solubilidad
ethanol: 5 mg/mL
temp. de almacenamiento
−20°C
cadena SMILES
O=C1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@H](CCCCC)O)[C@H](O)C1
InChI
1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,19+/m0/s1
Clave InChI
GMVPRGQOIOIIMI-DWKJAMRDSA-N
Información sobre el gen
human ... PTGER1(5731) , PTGER2(5732) , PTGIR(5739)
mouse ... Ptger1(19216) , Ptger2(19217) , Ptger3(19218) , Ptger4(19219)
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Aplicación
Acciones bioquímicas o fisiológicas
Prostaglandin E1 (PGE1) is a hormone synthesized from dihomo-γ-linolenic acid (DGLA) by the action of enzyme prostaglandin synthase.[4] It is a vasodilator and activates adenylate cyclase. It is majorly present in human semen and is a potent platelet aggregation inhibitor. PGE1 infusions is effective in treating limb ischemia and peripheral vascular disease.[5] It is unstable and is hydrolyzed to PGA1 in the lungs. Nanoparticle encapsulation of PGE1 is essential for its delivery at the vascular injury site.[6] It elicits vasodilator effects on the retinal artery and vein in central retinal artery occlusion (CRAO).[7] PGE1 and its synthetic analog misoprostol interact with E-prostanoid receptor 4 (EP4) and elicits protection in chronic myelogenous leukemia (CML). [8]
Palabra de señalización
Danger
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Acute Tox. 3 Oral
Código de clase de almacenamiento
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Los clientes también vieron
Yosuke Okamura et al.
Biophysical journal, 100(8), 1855-1863 (2011-04-21)
Eukaryotic cells respond to signaling molecules with picomolar to nanomolar sensitivities. However, molar concentrations give no suggestion of the sufficient number of molecules per cell and are confusing when referring to physiological situations in which signaling molecules act in an
Prostaglandins and thromboxanes.
B Samuelsson et al.
Annual review of biochemistry, 47, 997-1029 (1978-01-01)
Intravenous infusion of prostaglandin E1 therapy in extremity ischemia
Ramakrishna P
Indian Journal of Vascular and Endovascular Surgery, 4(2), 38-38 (2017)
Synthesis of prostaglandin E 1 phosphate derivatives and their encapsulation in biodegradable nanoparticles
Takeda M, et al.
Pharmaceutical Research, 26(7), 1792-1800 (2009)
Prostaglandin E1 and its analog misoprostol inhibit human CML stem cell self-renewal via EP4 receptor activation and repression of AP-1
Li F, et al.
Cell Stem Cell, 21(3), 359-373 (2017)
Artículos
Discover Bioactive Small Molecules for Lipid Signaling Research
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Is stability in solution information available for the product P5515?
Is stability in solution information available for the product P5515?
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What are the recommended storage temperature conditions for Prostaglandin E1 (P5515) when dissolved in acetone?
1 answer-
The solubility test is designed to ensure the product is free of foreign bodies or other unsoluble substances. Acetone was choosen for the solubility test because appears to have higher solubility in acetone than it does in ethanol. The Quality department will dissolve the product in acetone and discard the solution once the solubility test is complete. So there is no data for what is the preferred storage temperature and length of storage if using acetone as the solvent.
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