P4484

Purvalanol A

≥98% (HPLC), powder

• Sinónimos: 2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine, NG-60
• Fórmula empírica (notación de Hill): C₁₉H₂₅ClN₆O
• Número CAS: 212844-53-6
• Peso molecular: 388.89
• NACRES: NA.77
• PubChem Substance ID: 24898543
• UNSPSC Code: 12352200
• MDL number: MFCD02179211
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• assay: ≥98% (HPLC)
• form: powder
• solubility: methylene chloride: 50 mg/mL
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: CC(C)[C@H](CO)Nc1nc(Nc2cccc(Cl)c2)c3ncn(C(C)C)c3n1
• InChI: 1S/C19H25ClN6O/c1-11(2)15(9-27)23-19-24-17(22-14-7-5-6-13(20)8-14)16-18(25-19)26(10-21-16)12(3)4/h5-8,10-12,15,27H,9H2,1-4H3,(H2,22,23,24,25)/t15-/m0/s1
• InChI key: PMXCMJLOPOFPBT-HNNXBMFYSA-N

Descripción

Biochem/physiol Actions

Purvalanol A is found to inhibit ABCG2 (ATP-binding cassette G2) transporter in vitro. It is also known to attenuate cellular Src kinase action and induce cell cycle arrest at the G2 to M phase transition.

Purvalanol A is a potent, cell-permeable cyclin-dependent protein kinase (cdk) inhibitor.

Features and Benefits

This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)