P3988
20S Proteasome Fraction from rabbit
≥95% (SDS-PAGE), solution
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25 μG
$711.00
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25 μG
$711.00
About This Item
$711.00
Check Cart for Availability
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origen biológico
rabbit
Nivel de calidad
Ensayo
≥95% (SDS-PAGE)
Formulario
solution
mol peso
700 kDa
Nº de acceso UniProt
aplicaciones
cell analysis
Condiciones de envío
dry ice
temp. de almacenamiento
−70°C
Información sobre el gen
rabbit ... PSMA1(100352563) , PSMB1(100343622)
Descripción general
Manufactured for Sigma by Boston Biochem., Inc.
Aplicación
20S proteasome fraction from rabbit has been used as a positive control to determine proteasome activity.[1]
Acciones bioquímicas o fisiológicas
Catalytic core of the 26S proteasome that degrades polyubiquitinated proteins.
Hydrolyzes various peptide substrates and proteins with broad specificity in a non-ATP dependent process.
Forma física
Solution in 50 mM HEPES, pH 7.6, 150 mM sodium chloride, and 1 mM DTT, pH 7.6.
Código de clase de almacenamiento
10 - Combustible liquids
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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R Hough et al.
The Journal of biological chemistry, 262(17), 8303-8313 (1987-06-15)
We have purified two high molecular weight proteases approximately 400-fold from rabbit reticulocyte lysate. Both enzymes hydrolyze 125I-alpha-casein and 4-methylcoumaryl-7-amide peptides with tyrosine, phenylalanine, or arginine at the P1 position. Both are inhibited by hemin, thiol reagents, chymostatin, and leupeptin.
R L Stein et al.
Biochemistry, 35(13), 3899-3908 (1996-04-02)
In this paper, we report kinetic studies for the chymotryptic activity of the 20S proteasome. Major observations include the following: (1) Reaction progress curves that are recorded at concentrations of Suc-Leu-Leu-Val-Tyr-AMC greater than about 40 microM are biphasic and characterized
Examination of `lipotoxicity? in skeletal muscle of high-fat fed and ob/ob mice
S.M. Turpin
The Journal of Physiology (2009)
S M Turpin et al.
The Journal of physiology, 587(Pt 7), 1593-1605 (2009-02-11)
Excess lipid accumulation resulting from an elevated supply of plasma fatty acids is linked to the pathogenesis of the metabolic syndrome and heart disease. The term 'lipotoxicity' was coined to describe how lipid accumulation leads to cellular dysfunction and death
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