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P0113

Sigma-Aldrich

PQ401

≥98% (HPLC), powder

Sinónimos:

IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-N′-(2-methylquinolin-4-yl)urea

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10 MG
$177.65

$177.65

Precio de catálogo$187.00

Disponible para envío el01 de abril de 2025Detalles

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10 MG
$177.65

About This Item

Fórmula empírica (notación de Hill):
C18H16ClN3O2
Número de CAS:
196868-63-0
Peso molecular:
341.79
Número MDL:
MFCD00160558
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
24724567
NACRES:
NA.77

$177.65

Precio de catálogo$187.00

Disponible para envío el01 de abril de 2025Detalles

Solicitar un pedido a granel

Nivel de calidad

100

Ensayo

≥98% (HPLC)

Formulario

powder

color

white

solubilidad

DMSO: >10 mg/mL
H2O: <2 mg/mL

temp. de almacenamiento

2-8°C

cadena SMILES

COc1ccc(Cl)cc1NC(=O)Nc2cc(C)nc3ccccc23

InChI

1S/C18H16ClN3O2/c1-11-9-15(13-5-3-4-6-14(13)20-11)21-18(23)22-16-10-12(19)7-8-17(16)24-2/h3-10H,1-2H3,(H2,20,21,22,23)

Clave InChI

YBLWOZUPHDKFOT-UHFFFAOYSA-N

Aplicación

PQ401 has been used as:
  • an insulin growth factor-1 receptor (IGF-IR) inhibitor in H1299 cells to test its effect on migration suppression[1]
  • a reference inhibitor in dose-response measurements studies[2]
  • an IGF1R inhibitor in sirtuin 6 (SIRT6)-deficient cardiomyocytes to test its effect on hypertrophy inhibition[3]

Acciones bioquímicas o fisiológicas

PQ401 is an insulin growth factor-1 receptor (IGF-1R) inhibitor.
PQ401, a diaryl urea compound that serves as an anti-glioma agent.[4]

Características y beneficios

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the InsR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificados de análisis (COA)

Lot/Batch Number
023M4602V
027K46103
027K46102
027K46101
027K4610

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Monica Brenca et al.
The Journal of pathology, 238(4), 543-549 (2015-11-27)
Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. The vast majority of GISTs are driven by oncogenic activation of KIT, PDGFRA or, less commonly, BRAF. Loss of succinate dehydrogenase complex activity has been identified
Gang Xi et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 29(11), 2427-2438 (2014-05-20)
Insulin-like growth factor binding protein 2 (IGFBP-2) is important for acquisition of normal bone mass in mice; however, the mechanism by which IGFBP-2 functions is not defined. These studies investigated the role of IGFBP-2 in stimulating osteoblast differentiation. MC-3T3 preosteoblasts
Jung-Min Choi et al.
Lung cancer (Amsterdam, Netherlands), 90(2), 175-181 (2015-09-08)
Lung cancer is the commonly diagnosed cancer and is the leading cause of cancer-related mortality worldwide. The most prevalent form of lung cancer is NSCLC, comprising 80% of all lung cancer cases, and epidermal growth factor receptor (EGFR) is frequently
R Moriev et al.
Acta naturae, 5(2), 90-99 (2013-07-03)
The aim of this study was to identify small molecule compounds that inhibit the kinase activity of the IGF1 receptor and represent novel chemical scaffolds, which can be potentially exploited to develop drug candidates that are superior to the existing
Maria Giovanna Scioli et al.
Journal of tissue engineering and regenerative medicine, 11(8), 2398-2410 (2016-04-15)
Osteochondral lesions due to injury or other pathology commonly result in the development of osteoarthritis and progressive joint destruction. Bioengineered scaffolds are widely studied for regenerative surgery strategies in osteochondral defect management, also combining the use of stem cells, growth
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