P0078

Anti-PMP22 antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

• Sinónimos: Anti-GAS3, Anti-Growth arrest-specific 3, Anti-Peripheral myelin protein 22
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 200
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• Formulario: buffered aqueous solution
• mol peso: antigen ~22 kDa
• reactividad de especies: human
• concentración: ~1.0 mg/mL
• técnicas: immunohistochemistry: 2.5-5 μg/mL using biotin/ExtrAvidin^™-Peroxidase staining of formalin-fixed, paraffin-embedded human spinal cord sections
• Nº de acceso UniProt: Q01453
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... PMP22(5376) ; mouse ... Pmp22(18858) ; rat ... Pmp22(24660)

Descripción

Descripción general

PMP22 (peripheral myelin protein-22) is a tetraspan integral membrane protein, that contains four putative transmembrane domains. It is expressed in the peripheral nervous system. PMP22 is produced by myelinating Schwann cells. It is an important constituent of peripheral myelin. This gene is mapped to human chromosome 17p11.2.

Especificidad

Anti-PMP22 recognizes human PMP22.

Inmunógeno

synthetic peptide corresponding to amino acid residues 118-133 of human PMP22, with an added cysteine, conjugated to KLH. The corresponding sequence differs by 3 amino acids in rat and mouse.

Acciones bioquímicas o fisiológicas

PMP22 (peripheral myelin protein-22) participates in the progression of CNS (central nervous system) myelin. It modulates self-renewal and chemoresistance of gastric cancer cells. Mutation in PMP22 results in Charcot-Marie tooth disease.

PMP22 plays a role in peripheral nerve myelin formation, cell-cell interactions, and cell proliferation. Overexpression of PMP22 is implicated in the neoplastic transformation of normal tissue to pre-malignant lesions and cancer of the pancreas and osteoblasts.

Forma física

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Almacenamiento y estabilidad

For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze at -20 °C in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Información legal

BiotinTag is a trademark of Sigma-Aldrich Co. LLC

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)