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P0034

Sigma-Aldrich

20S-Protopanaxatriol

Sinónimos:

20(S)-APPT, g-PPT

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About This Item

Fórmula empírica (notación de Hill):
C30H52O4
Número de CAS:
34080-08-5
Peso molecular:
476.73
MDL number:
MFCD11041271
UNSPSC Code:
12352200

form

powder

Quality Level

200

storage temp.

2-8°C

InChI

1S/C30H52O4/c1-18(2)10-9-13-30(8,34)19-11-15-28(6)24(19)20(31)16-22-27(5)14-12-23(33)26(3,4)25(27)21(32)17-29(22,28)7/h10,19-25,31-34H,9,11-17H2,1-8H3/t19-,20+,21-,22+,23-,24-,25-,27+,28-,29+,30-/m0/s1

InChI key

SHCBCKBYTHZQGZ-PHFGEWBZSA-N

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General description

A ginsenoside metabolite that has been linked to endothelial cell function via the glucocortoid receptor (GR) and the oestrogen receptor (ER).

Application

20S-Protopanaxatriol (g-PPT), a dammarane-type tetracyclic terpene sapogenin, may be used to study its binding to and modulation of cell function via glucocortoid (GR) and oestrogen (ER) receptors.

Biochem/physiol Actions

A metabolites of ginsenoside, protopanaxatriol (g-PPT), could modulate endothelial cell functions through the glucocorticoid receptor (GR) and oestrogen receptor (ER).

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Yaping Ji et al.
Pain, 152(5), 1182-1191 (2011-03-12)
We previously reported that 17β-estradiol (E2) is pronociceptive in a visceral pain model in the rat. Subcutaneously (s.c.) administered E2 reversed the decrease in the colorectal distention (CRD)-evoked visceromotor response produced by ovariectomy (OVx) and CRD-induced nociceptive responses were greater
Jessica Santollo et al.
Physiology & behavior, 97(2), 193-198 (2009-03-04)
Estrogens exert many of their behavioral effects by binding to nuclear estrogen receptor (ER) proteins, ERalpha and ERbeta. Recent studies involving ER knockout mice and selective ER agonists suggest that estradiol's anorexigenic effect is mediated via activation of ERalpha. To
Kyu Lee Han et al.
Biological & pharmaceutical bulletin, 29(1), 110-113 (2006-01-06)
Peroxisome proliferator-activated receptor gamma (PPARgamma), a member of the nuclear receptor of ligand-activated transcription factors, regulates the expression of key genes involved in lipid and glucose metabolism or adipocyte differentiation. Ligands for this receptor have emerged as potent insulin sensitizers
Rui Liu et al.
Fitoterapia, 81(8), 1079-1087 (2010-07-16)
Effects of protopanaxdiol (PDG) and protopanaxatriol (PTG) types of ginsenosides isolated from the leaves of American ginseng on porcine pancreatic lipase activity were determined in vitro. PDG inhibited the pancreatic lipase activity in a dose-dependent manner at the concentrations of
So Young Hong et al.
Journal of agricultural and food chemistry, 60(12), 3086-3091 (2012-03-03)
Nitric oxide (NO) produced by endothelial nitric oxide synthase (eNOS) is a fundamental regulator of systemic blood pressure. Ginsenosides from Panax ginseng have been investigated in vitro for the molecular and biochemical mechanisms by which they stimulate NO release in
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