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O9387

Sigma-Aldrich

Oxatomide

≥99%

Sinónimos:

1-[3-[4-(Diphenylmethyl)-1-piperazinyl]propyl]-1,3-dihydro-2H-benzimidazol-2-one

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10 MG
$233.10

$233.10

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Disponible para envío el31 de marzo de 2025Detalles

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10 MG
$233.10

About This Item

Fórmula empírica (notación de Hill):
C27H30N4O
Número de CAS:
60607-34-3
Peso molecular:
426.55
Número CE:
262-320-9
Número MDL:
MFCD00211147
Código UNSPSC:
51111800
ID de la sustancia en PubChem:
24278615
NACRES:
NA.77

$233.10

Precio de catálogo$333.00Ahorre 30 %

Disponible para envío el31 de marzo de 2025Detalles

Ensayo

≥99%

Formulario

powder

color

white

solubilidad

DMSO: soluble
ethanol: soluble

emisor

Johnson & Johnson

cadena SMILES

O=C1Nc2ccccc2N1CCCN3CCN(CC3)C(c4ccccc4)c5ccccc5

InChI

1S/C27H30N4O/c32-27-28-24-14-7-8-15-25(24)31(27)17-9-16-29-18-20-30(21-19-29)26(22-10-3-1-4-11-22)23-12-5-2-6-13-23/h1-8,10-15,26H,9,16-21H2,(H,28,32)

Clave InChI

BAINIUMDFURPJM-UHFFFAOYSA-N

Información sobre el gen

human ... DRD3(1814)

Descripción general

Oxatomide, a histamine H1-receptor antagonist,[1] is bound at high levels to plasma proteins in human blood.[2]

Acciones bioquímicas o fisiológicas

Oxatomide is an anti-allergy compound. It suppresses platelet activating factor (PAF)-induced bronchoconstriction and inhibits leukotriene production.
Oxatomide, found in several antihistamines, can suppress mast cell degranulation. It can be used as an alternative to individuals with allergic rhinitis who do not or poorly respond to more established antihistamines.[2] Oxatomide exhibits both antihistamine and anti-inflammatory properties. It exhibits therapeutic effects against asthma[1] and vulvar lichen sclerosus.[3]

Características y beneficios

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictogramas

Exclamation mark
GHS07

Palabra de señalización

Warning

Frases de peligro

H302

Clasificaciones de peligro

Acute Tox. 4 Oral

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
MKCT6989
MKCT8869
MKCR1623
MKCR7151
MKCP1201

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Hiroyuki Mizuguchi et al.
Pharmaceutics, 12(6) (2020-06-12)
H1-antihistamines antagonize histamine and prevent it from binding to the histamine H1 receptor (H1R). Some of them also act as inverse agonists, which are more potent than pure antagonists because they suppress the constitutive H1R activity. Bilastine is a non-sedative
H Kimata
European journal of clinical investigation, 33(6), 513-517 (2003-06-11)
Playing video games causes physical and psychological stress, including increased heart rate and blood pressure and aggression-related feelings. Use of mobile phones is very popular in Japan, and frequent ringing is a common and intrusive part of Japanese life. Atopic
Mariko Domae et al.
The Journal of allergy and clinical immunology, 111(3), 567-572 (2003-03-19)
Eosinophils accumulated in sites of allergic inflammation are thought to play a crucial role in the pathogenesis of allergic disorders including asthma, allergic rhinitis, and atopic dermatitis, and tissue eosinophilia is attributable to increased eosinophil survival or decreased eosinophil apoptosis.
D M Richards et al.
Drugs, 27(3), 210-231 (1984-03-01)
Oxatomide is an orally active H1-histamine receptor antagonist which, as appears to occur with some other antihistamines, also inhibits mast cell degranulation. Oxatomide has demonstrated response rates similar to those with other more established members of its drug class in
M Origoni et al.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 55(3), 259-264 (1996-12-01)
The treatment of vulvar lichen sclerosus has greatly improved in recent years, with the introduction of new pharmacological approaches and reconsideration of the traditional ones. Oxatomide is a molecule with both antihistamine and inhibiting activities for the inflammatory response, which
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