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O0766

Sigma-Aldrich

ONO-RS-082

≥97% (HPLC)

Sinónimos:

2-(p-Amylcinnamoyl)amino-4-chlorobenzoic acid, 4-Chloro-2-[[1-oxo-3-(4-pentylphenyl)-2-propen-1-yl]amino]-benzoic acid

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About This Item

Fórmula empírica (notación de Hill):
C21H22ClNO3
Número de CAS:
99754-06-0
Peso molecular:
371.86
UNSPSC Code:
41106300
NACRES:
NA.77

assay

≥97% (HPLC)

form

powder

shelf life

Do not freeze

storage condition

protect from light

color

white

solubility

DMSO: ≥20 mg/mL

storage temp.

room temp

InChI

1S/C21H22ClNO3/c1-2-3-4-5-15-6-8-16(9-7-15)10-13-20(24)23-19-14-17(22)11-12-18(19)21(25)26/h6-14H,2-5H2,1H3,(H,23,24)(H,25,26)/b13-10+

InChI key

MDVFITMPFHDRBZ-JLHYYAGUSA-N

Biochem/physiol Actions

ONO-RS-082 is a reversible phospholipase A2 inhibitor.

Features and Benefits

This compound is featured on the Phospholipase A2 page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Environment
GHS09

signalword

Warning

hcodes

H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Y Sugita et al.
European journal of pharmacology, 365(1), 77-89 (1999-02-13)
In order to examine some possibly misleading conclusions of the pharmacological analysis of the signal transduction pathways of gastric acid secretion, we evaluated various agents including inhibitors of protein kinase C, cyclic AMP-dependent protein kinase, phospholipase C, phospholipase A2, lipoxygenase
T Takeuchi et al.
Japanese journal of pharmacology, 87(4), 309-317 (2002-02-07)
The origin of Ca2+ necessary for carbachol (CCh)-induced contraction of longitudinal muscle of the proximal colon of rats was studied. CCh induced contraction of the muscle consisting of two phases, phasic and tonic phases, with a concomitant biphasic increase in
K L Byron
Circulation research, 78(5), 813-820 (1996-05-01)
[Arg8]-vasopressin (AVP) is both a potent vasoconstrictor and a mitogen for vascular smooth muscle cells. AVP binds to a single class of receptors (V1a) in the A7r5 rat aortic smooth muscle cell line (Kd approximately 2 nmol/L). Stimulation of these
L Domínguez et al.
International journal of andrology, 19(4), 248-252 (1996-08-01)
Phospholipase A2 (PLA2, EC 3.1.1.4) is involved in the cascade of signalling events leading to the acrosome reaction in human spermatozoa. In order to study the role of PLA2 in the acrosome reaction triggered by GTP gamma S, a non-hydrolizable
H Nishino et al.
The American journal of physiology, 274(3 Pt 1), G525-G534 (1998-04-08)
We investigated the structural requirements for bombesin (BB)-like peptides to stimulate amylase secretion in rat pancreatic acini and examined the responsible intracellular signal transduction pathways. The tetradecapeptide BB-(1-14) was a full agonist, whereas the heptapeptide BB-(8-14) did not evoke amylase
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Phospholipase A2

Phospholipase A2 (PLA2) enzymes hydrolyze glycerophospholipids, yielding arachidonic acid; inhibition targets eicosanoid biosynthesis.

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