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N4751

Sigma-Aldrich

Nicotinuric acid

Sinónimos:

Nicotinylglycine

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About This Item

Fórmula empírica (notación de Hill):
C8H8N2O3
Número de CAS:
583-08-4
Peso molecular:
180.16
EC Number:
209-497-0
MDL number:
MFCD00023578
UNSPSC Code:
12352106
PubChem Substance ID:
24897709
NACRES:
NA.79

assay

≥98% (with NaOH, titration)

form

powder

color

white

SMILES string

OC(=O)CNC(=O)c1cccnc1

InChI

1S/C8H8N2O3/c11-7(12)5-10-8(13)6-2-1-3-9-4-6/h1-4H,5H2,(H,10,13)(H,11,12)

InChI key

ZBSGKPYXQINNGF-UHFFFAOYSA-N

Categorías relacionadas

Biochem/physiol Actions

Nicotinuric acid (NUA) is a metabolite of niacin/vitamin B. Measurement of NUA levels in urine is used to indicate possible elevated nicotinamide adenine dinucleotide (NAD) catabolism. NUA may be used as a reference (standard curve) in the analysis of NAD and NUA catabolism. Nicotinic acid reduces triglycerides and increases high density lipoprotein(HDL) cholesterol.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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M Iwaki et al.
Journal of chromatography. B, Biomedical applications, 661(1), 154-158 (1994-11-04)
The concentrations of nicotinic acid (NiAc) and nicotinuric acid (NiUAc), a major metabolite of NiAc, were simultaneously determined in urine using solid-phase extraction (cation-exchange extraction) and reversed-phase high-performance liquid chromatography with ultraviolet detection. The intra- and inter-day precision studies showed
C Daniel Meyers et al.
Atherosclerosis, 192(2), 253-258 (2006-09-02)
Nicotinic acid is a safe, broad-spectrum lipid agent shown to prevent cardiovascular disease, yet its widespread use is limited by the prostaglandin D2 (PGD2) mediated niacin flush. Previous research suggests that nicotinic acid-induced PGD2 secretion is mediated by the skin
R H Stern et al.
Metabolism: clinical and experimental, 41(8), 879-881 (1992-08-01)
The possibility that differences in metabolism might underly the differences in efficacy and toxicity between time-release and unmodified formulations of nicotinic acid was investigated by measuring 24-hour urinary excretion of metabolites in 10 subjects who received both forms. Nicotinic acid
M Iwaki et al.
Drug metabolism and disposition: the biological fate of chemicals, 24(7), 773-779 (1996-07-01)
The pharmacokinetics of nicotinic acid (NiAc) and nicotinuric acid (NiUAc), the major metabolite of NiAc, and the dose dependency of these pharmacokinetics were determined in rats. Intravenous injections of 2, 5, 15, and 45 mg/kg of NiAc and 5 and
H L Figge et al.
Journal of clinical pharmacology, 28(12), 1136-1140 (1988-12-01)
We tested an inexpensive controlled-release nicotinic acid product (Bronson Pharmaceuticals, LaCanada, CA) and compared it with the standard, more expensive, controlled release product, Nicobid (Rorer Pharmaceuticals), by measuring the 24 hour urinary recovery of nicotinic and nicotinuric acids from ten
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