N3663

Anti-NeuroD1 antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

• Sinónimos: Anti-BETA2, Anti-BHF-1, Anti-NDF1, Anti-Neurogenic differentiation factor1
• UNSPSC Code: 12352203
• NACRES: NA.41
• MDL number: MFCD03097085
• Conjugate: unconjugated
• Clone: polyclonal
• Application: WB
• Citations: 4

Propiedades

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen ~45 kDa (doublet bands)
• species reactivity: human, rat, mouse
• packaging: antibody small pack of 25 μL
• concentration: ~1 mg/mL
• technique(s): western blot: 0.5-1 μg/mL using whole extracts of HEK-293T cells expressing human NeuroD1
• UniProt accession no.: Q13562
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... NEUROD1(4760) ; mouse ... Neurod1(18012) ; rat ... Neurod1(29458)

Descripción

General description

NeuroD1 gene is mapped to human chromosome 2q31.3.

Neuronal differentiation 1 (NEUROD1) is a transcription factor which is highly expressed in the brain, pancreas and retina.

Immunogen

synthetic peptide corresponding to amino acids 76-91 of human NeuroD1 conjugated to BSA. The corresponding sequence differs in mouse and rat by two and three amino acids, respectively.

Application

Anti-NeuroD1 antibody produced in rabbit has been used in chromatin immunoprecipitation and immunoblotting.

Biochem/physiol Actions

Anti-NeuroD1 specifically recognizes human, mouse and rat NeuroD1.

NeuroD1 is a basic helix-loop-helix (bHLH) transcription factor, which regulates the fate of specific neuronal, endocrine and retinal cells.

Neuronal differentiation 1 (NEUROD1) binds to promoters and regulates gene expression. It can also enhance tumor cell survival in lung tumors. Mutations in the gene encoding NEUROD1 have been associated with neurological problems and early-onset diabetes.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Preparation Note

For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Clase de almacenamiento: 10 - Combustible liquids
• ¿Qué está pasando?: nwg
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable
• EPI (equipos de protección individual): Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)