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MAK218

Sigma-Aldrich

Tace Inhibitor Screening Assay Kit

Sufficient for 100 Fluorometric tests

Sinónimos:

ADAM Metallopeptidase Domain 17, ADAM17 Inhibitor Screening Assay Kit, Tumor Necrosis Factor-α-converting enzyme Inhibitor Screening Kit

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About This Item

EC Number:
200-664-3
UNSPSC Code:
12352200
NACRES:
NA.84

detection method

fluorometric

storage temp.

−20°C

Gene Information

human ... ADAM17(6868)
mouse ... ADAM17(11491)
rat ... ADAM17(57027)

General description

Tumor necrosis factor-a converting enzyme (TACE; ADAM17) is a member of the ADAM (A Disintegrin And Metalloprotease) protein family implicated in cell-cell and cell-matrix interactions. TACE activates Notch signaling in the epidermal cells and has a critical function in the maintenance of barrier immunity. It is also involved in neurogenesis and muscle development.

Application

Tace Inhibitor Screening Assay Kit has been used in TACE (TNFa converting enzyme) activity assays.[1]

Features and Benefits

Compatible with high-throughput handling systems.

Suitability

Suitable for the screening of inhibitors of TACE.

Principle

The TACE Inhibitor Screening Assay Kit is a rapid, simple and sensitive assay that is suitable for high throughput screening of TACE inhibitors. TACE hydrolyzes a FRET-tagged substrate to release a fluorescent product (λex = 318/ λem = 449 nm), proportional to the enzymatic activity present.

Solo componentes del kit

Referencia del producto
Descripción
  • TACE Assay Buffer
  • TACE Substrate
  • TACE Enzyme
  • Inhibitor Control, 0.1 mM GM6001

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H334

Hazard Classifications

Resp. Sens. 1

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

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Certificados de análisis (COA)

Lot/Batch Number
7C19K03660

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Joseph Dosch et al.
Oncotarget, 8(39), 65090-65099 (2017-10-17)
ADAM17 (a disintegrin and metalloproteinase 17)/TACE (TNFα converting enzyme) has emerged as a potential therapeutic target in colorectal cancer (CRC) and other cancers, due in part to its role in regulating various tumor cell surface proteins and growth factors and

Questions

  1. What is the quantity of Zinc present in the Assay buffer?

    1 answer

    1. The quantity of zinc is considered proprietary and cannot be disclosed.

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