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M9149

Mepartricin

Name: Mepartricin
Brand: SIGMA

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About This Item

Número de CAS:

11121-32-7

MDL number:

MFCD00070325

UNSPSC Code:

51101500

PubChem Substance ID:

329818084

potency

3700 units Mepartricin per mg

color

yellow to yellow with tan cast powder

solubility

DMF: 50 mg/mL, slightly hazy, red to red-brown

antibiotic activity spectrum

fungi

mode of action

cell wall synthesis | interferes

storage temp.

2-8°C

SMILES string

COC(=O)C1C(O)CC2(O)CC(O)CC(O)CC(O)CC(O)CC(=O)CC(O)CC(=O)OC(C(C)CCC(O)CC(=O)c3ccc(N)cc3)C(C)\C=C\C=C\C=C\C=C\C=C\C=C\C=C\C(CC1O2)O[C@@H]4O[C@H](C)[C@@H](O)[C@H](N)[C@@H]4O

InChI

1S/C59H86N2O19/c1-35-17-15-13-11-9-7-5-6-8-10-12-14-16-18-47(78-58-55(73)53(61)54(72)37(3)77-58)32-50-52(57(74)76-4)49(70)34-59(75,80-50)33-46(68)29-44(66)27-42(64)25-41(63)26-43(65)28-45(67)31-51(71)79-56(35)36(2)19-24-40(62)30-48(69)38-20-22-39(60)23-21-38/h5-18,20-23,35-37,40-42,44-47,49-50,52-56,58,62-64,66-68,70,72-73,75H,19,24-34,60-61H2,1-4H3/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t35?,36?,37-,40?,41?,42?,44?,45?,46?,47?,49?,50?,52?,53+,54-,55+,56?,58+,59?/m1/s1

InChI key

GIDIUOCSTCGLRW-QJSPMWJNSA-N

General description

Chemical structure: macrolide

Application

Mepartricin is a polyene antibacterial with antifungal and antiprotozoal activity. It is an Amphotericin B(AmB) analogue and has been used to study scrapie. It is used as an antibiotic supplement in cell culture.

Mepartricin is used in studies on sterol biosynthesis and bacterial cell membranes. It may be incorporated into liposomes

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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[Multicenter clinical study of the effects of once daily administration of mepartricin 150.000 U. in benign prostatic hypertrophy].

E Pisani

Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica, 67(4), 223-230 (1995-09-01)

The effects of partricin methyl ester, administered to 481 BPH patients at the dose of 150.000 U as a single administration at night for 90 days were studied in the course of a multicentre study. The favourable evolution of the

Effects of mepartricin, a polyene macrolide antibiotic, on estrogen-induced hyperplastic growth of the dorsolateral prostate and seminal vesicle in immature castrated rats.

Shuji Shakuto et al.

Scandinavian journal of urology and nephrology, 39(5), 358-365 (2005-11-01)

To investigate the effects of mepartricin, a polyene macrolide antibiotic, on estrogen-induced hyperplastic prostate and seminal vesicle (SV) growth in castrated rats. Immature rats aged 3 weeks were castrated and left untreated for 1 week. Then, 17beta-estradiol benzoate (E(2)-BA) was

[Mepartricin in BPH. A new dosage approach].

D Prezioso et al.

Minerva urologica e nefrologica = The Italian journal of urology and nephrology, 48(2), 117-120 (1996-06-01)

The authors assessed the validity of a treatment with mepartricin in BPH at the dose of 150,000 U in a once-a-day evening administration for 6 months. The results from the controlled study were compared with those obtained in a homogeneous

Role of mepartricin in category III chronic nonbacterial prostatitis/chronic pelvic pain syndrome: a randomized prospective placebo-controlled trial.

Aldo Franco De Rose et al.

Urology, 63(1), 13-16 (2004-01-31)

To verify the efficacy of mepartricin versus placebo with regard to symptom improvement in patients with chronic nonbacterial prostatitis/chronic pelvic pain syndrome (CPPS) and to verify a relation between hormonal levels and clinical improvement in these patients. Twenty-six patients with

[Can mepartricin be considered an antiandrogenic drug?].

C Lubrano et al.

Minerva urologica e nefrologica = The Italian journal of urology and nephrology, 44(2), 113-116 (1992-04-01)

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