M8440
Anti-MCH antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
Sinónimos:
MCH Antibody - Anti-MCH antibody produced in rabbit, Mch Antibody, Anti-Melanin-Concentrating Hormone
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200 μL
$530.00
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200 μL
$530.00
About This Item
Productos recomendados
origen biológico
rabbit
conjugado
unconjugated
forma del anticuerpo
IgG fraction of antiserum
tipo de anticuerpo
primary antibodies
clon
polyclonal
Formulario
buffered aqueous solution
reactividad de especies
human
técnicas
indirect ELISA: 1:2,500
microarray: suitable
Nº de acceso UniProt
Condiciones de envío
dry ice
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... PMCH(5367)
Categorías relacionadas
Descripción general
Melanin-concentrating hormone (MCH) is a circulating 19-amino acid residue cyclic neuropeptide present in hypothalamus. In mammals, MCH is a, encoded by the precursor pro-melanin concentrating hormone (PMCH). It was first discovered in fish and subsequently in mammalian (rat). MCH perikarya is confined largely to the lateral hypothalamus area (LHA) and the adjacent zon incerta with extensive neuronal projections throughout the brain. MCH is detected in basal ganglia, neocortex, cerebellum, thymus, brown adipose tissue, duodenum, and testis. The structure of MCH is highly conserved among species.
Inmunógeno
synthetic peptide corresponding to human melanin-concentrating hormone conjugated to KLH. The MCH sequence is identical in many species including rat, mouse, and pig.
Aplicación
Anti-MCH antibody may be used at a working dilution of 1:30000 for RIA. For immunohistochemistry of mouse hypothalamus sections, a working antibody dilution of 1:200 may be used. The antibody has been used for immunoblotting in cytoplasmic extracts of T cells at a concentration of 5.7 μg/ml. The antibody is suitable for protein microarray.
Anti-MCH antibody produced in rabbit has been used in radioimmunoassay and immunohistochemistry.
Acciones bioquímicas o fisiológicas
MCH mRNA is overexpressed and up-regulated during fasting in the hypothalamus of ob/ob mice as well as rats. Injection of MCH into the lateral ventricles in rats promote increased food consumption. In addition, knockout mice lacking MCH gene are lean and hypophagic and show an increase in metabolic rate. In contrast, overexpression of MCH in transgenic mice leads to obesity and insulin resistance.
Forma física
Solution in phosphate buffered saline containing 15 mM sodium azide.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
12 - Non Combustible Liquids
Clase de riesgo para el agua (WGK)
nwg
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance
Ludwig DS, et al.
The Journal of Clinical Investigation, 107(3), 379-386 (2001)
Balázs Gerics et al.
Acta biologica Hungarica, 68(1), 14-21 (2017-03-23)
Melanin-concentrating hormone (MCH), the neuropeptide produced mainly in the hypothalamus, plays an operative role in regulating food intake and the sleep/wake cycle. Considering that these physiological functions pursue diurnal variations, we checked whether the total hypothalamic MCH level depends on
J Naufahu et al.
The Journal of endocrinology, 232(3), 513-523 (2017-01-06)
Melanin-concentrating hormone (MCH) is a hypothalamic neuropeptide with a well-characterised role in energy homeostasis and emergent roles in diverse physiologic functions such as arousal, mood and reproduction. Work to date has predominantly focused on its hypothalamic functions using animal models;
Ilona C Kokay et al.
Journal of neuroendocrinology, 32(2), e12827-e12827 (2020-01-10)
A population of neurones in the medial part of the medial preoptic area (mPOA) transiently express melanin-concentrating hormone (MCH) in mid to late lactation in the rat, and this expression disappears on weaning. Prolactin is known to mediate many of
Gabriel E Bertolesi et al.
Pigment cell & melanoma research, 32(4), 510-527 (2019-02-23)
Different camouflages work best with some background matching colour. Our understanding of the evolution of skin colour is based mainly on the genetics of pigmentation ("background matching"), with little known about the evolution of the neuroendocrine systems that facilitate "background
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