M6053

Anti-Matrix Metalloproteinase-3, Propeptide Region antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution

• Sinónimos: Anti-MMP-3
• Número MDL: MFCD03455413
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 200
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• Formulario: buffered aqueous glycerol solution
• mol peso: antigen 59 kDa; antigen (pro-form) 57 kDa
• reactividad de especies: human
• concentración: ~1 mg/mL
• técnicas: western blot: 1:1000
• Nº de acceso UniProt: P08254
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... MMP3(4314)

Descripción

Descripción general

Matrix metalloproteinase-3 (MMP-3) is also known as stromelysin 1 and the gene encoding it is localized on human chromosome 11q22.3.

Especificidad

Reacts with reduced and to a lesser extent non-reduced MMP-3. The propeptide is shed after activation; therefore, the antibody recognizes the pro-form of MMP-3 and not the active forms. May be used to distinguish the latent from the active form of MMP-3. Recognizes Stromelysin-1 and Stromelysin-2, but not Stromelysin-3 or other MMP family members.

Inmunógeno

synthetic peptide corresponding to the propeptide region of human matrix metalloproteinase-3 (stromelysin-1).

Acciones bioquímicas o fisiológicas

Matrix metalloproteinase-3 (MMP-3) plays an important role in cartilage degradation. It can act on a large number of substrates like type II, III, IV, IX and X collagens, laminin and fibronectin. MMP-3 can also activate other matrix metalloproteinases like MMP-1,-2 and -13. It has been associated with rheumatoid arthritis.

Forma física

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 50% glycerol and 15 mM sodium azide.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids