M4603
Acetyl-[Nle4, Asp5, D-2-Nal7, Lys10]-cyclo-α-Melanocyte Stimulating Hormone Amide Fragment 4-10
≥95% (HPLC), Melanocortin-4 receptor antagonist
Sinónimos:
SHU9119
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| Tamaño de envase | SKU | Disponibilidad | Precio |
|---|---|---|---|
| 1 mg | Disponible para enviar HOYdesdeMILWAUKEE | $493.00 $419.05 |
Acerca de este artículo
Fórmula empírica (notación de Hill):
C54H71N15O9
Peso molecular:
1074.24
UNSPSC Code:
51111800
NACRES:
NA.32
MDL number:
$419.05
Precio de catálogo$493.00Ahorre 15 %Promoción solo por Internet
Disponible para enviar HOYDetalles
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Permítanos ayudarleNombre del producto
Acetyl-[Nle4, Asp5, D-2-Nal7, Lys10]-cyclo-α-Melanocyte Stimulating Hormone Amide Fragment 4-10, ≥95% (HPLC)
Quality Level
assay
≥95% (HPLC)
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... POMC(5443)
Biochem/physiol Actions
Screening analogs of the cyclic lactam melanocortin agonist MTII led to the identification of the agoutimimetic SHU9119. This compound shares pharmacological properties with the agouti peptide in that it is a potent antagonist of the melanocortin-4 receptor and a less potent antagonist of the melanocortin-3 receptor.
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Este artículo | |||
|---|---|---|---|
| assay ≥95% (HPLC) | assay ≥95% (HPLC) | assay ≥97% (HPLC) | assay ≥95% (HPLC) |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| Gene Information human ... POMC(5443) | Gene Information human ... POMC(5443) | Gene Information human ... POMC(5443) | Gene Information human ... POMC(5443) |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
![Acetyl-[Nle4, Asp5, D-2-Nal7, Lys10]-cyclo-α-Melanocyte Stimulating Hormone Amide Fragment 4-10 ≥95% (HPLC)](/deepweb/assets/sigmaaldrich/product/images/396/349/c488513c-1ea5-4f2a-b125-6b9a1940d8fd/640/c488513c-1ea5-4f2a-b125-6b9a1940d8fd.jpg)
![[D-Trp7, Ala8, D-Phe10]-α-Melanocyte Stimulating Hormone Amide Fragment 6-11 ≥97% (HPLC)](/deepweb/assets/sigmaaldrich/product/structures/137/006/013a88e0-770d-44fb-8438-97b5d2d79d5c/640/013a88e0-770d-44fb-8438-97b5d2d79d5c.png)
![[Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone trifluoroacetate salt ≥95% (HPLC)](/deepweb/assets/sigmaaldrich/product/structures/276/187/9733edf4-6412-4f2b-8cc6-c3f9f3425d4d/640/9733edf4-6412-4f2b-8cc6-c3f9f3425d4d.png)
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Anna Fosch et al.
International journal of molecular sciences, 24(2) (2023-01-22)
Sensing of long-chain fatty acids (LCFA) in the hypothalamus modulates energy balance, and its disruption leads to obesity. To date, the effects of saturated or unsaturated LCFA on hypothalamic-brown adipose tissue (BAT) axis and the underlying mechanisms have remained largely
V J Hruby et al.
Journal of medicinal chemistry, 38(18), 3454-3461 (1995-09-01)
The cloning of the melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH) receptors (MC1-R and MC2-R, respectively) recently has led to the identification of three additional melanocortin receptors, MC3-R, MC4-R, and MC5-R. The MC2 receptor primarily recognizes only ACTH peptides, but
W Fan et al.
Nature, 385(6612), 165-168 (1997-01-09)
Dominant alleles at the agouti locus (A) cause an obesity syndrome in the mouse, as a consequence of ectopic expression of the agouti peptide. This peptide, normally only found in the skin, is a high-affinity antagonist of the melanocyte-stimulating hormone
Número de artículo de comercio global
| SKU | GTIN |
|---|---|
| M4603-1MG | 04061826284902 |