As reported in the PROPERTIES section, this product is soluble in H2O at 50 mg/mL yielding a clear, colorless solution.
M4263
Malonyl coenzyme A lithium salt
≥90% (HPLC)
Sinónimos:
Malonyl CoA lithium salt
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5 MG
$154.00
10 MG
$295.00
25 MG
$591.00
100 MG
$1,880.00
$154.00
Disponible para envío el07 de abril de 2025Detalles
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5 MG
$154.00
10 MG
$295.00
25 MG
$591.00
100 MG
$1,880.00
About This Item
Fórmula empírica (notación de Hill):
C24H38N7O19P3S · xLi+
Número de CAS:
Peso molecular:
853.58 (free acid basis)
Código UNSPSC:
41106305
ID de la sustancia en PubChem:
NACRES:
NA.51
$154.00
Disponible para envío el07 de abril de 2025Detalles
Productos recomendados
Ensayo
≥90% (HPLC)
Formulario
powder
solubilidad
H2O: soluble 50 mg/mL protein, clear, colorless
temp. de almacenamiento
−20°C
cadena SMILES
[Li].CC(C)(COP(O)(=O)OP(O)(=O)OCC1OC(C(O)C1OP(O)(O)=O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(O)=O
InChI
1S/C24H38N7O19P3S.Li/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31;/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41);
Clave InChI
OPIJLICRFQMMJH-UHFFFAOYSA-N
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Aplicación
Malonyl coenzyme A lithium salt has been used:
- in Krebs Ringer bicarbonate medium for preincubation of trypsinized and re-suspended fibroblast for fatty acid oxidation assay[1]
- in HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid) buffer used for scintillation proximity assay for fatty acid synthase[2]
- as an internal standard in the reaction mixture used for succinyl-CoA ligase assay[3]
Acciones bioquímicas o fisiológicas
Coenzyme A functions as an acyl group carrier, acetyl-CoA. Malonyl Coenzyme A is a coenzyme A derivative that is utilized in fatty acid and polyketide synthesis and in the transport of α-ketoglutarate across the mitochondrial membrane. Malonyl CoA is formed by the Acetyl CoA Carboxylase-mediated carboxylation of acetyl CoA. Malonyl-CoA is exclusively used as the extender unit in the synthesis of bacterial aromatic polyketides.
Malonyl coenzyme A is a coenzyme A derivative that is utilized in fatty acid and polyketide synthesis and in the transport of α-ketoglutarate across the mitochondrial membrane. Malonyl CoA is formed by the Acetyl CoA Carboxylase-mediated carboxylation of acetyl CoA. Metabolism of glucose also yields malonyl coenzyme A. It allosterically blocks the action of carnitine palmitoyltransferase 1, which affects the transfer of long chain fatty acids into mitochondria. Inactivation of fatty acid synthase results in excess malonyl coenzyme A which leads to anorexia.[4]
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
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Characterization of fatty acid synthase activity using scintillation proximity
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R G Summers et al.
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Streptomyces glaucescens, a Gram-positive soil bacterium, produces the polyketide antibiotic tetracenomycin (Tcm) C. To study possible biochemical connections between the biosynthesis of bacterial fatty acids and polyketides, the abundant acyl carrier protein (ACP) detected throughout the growth of the tetracenomycin
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Recent studies have revealed that mitochondria are able to synthesize fatty acids in a malonyl-CoA/acyl carrier protein (ACP)-dependent manner. This pathway resembles bacterial fatty acid synthesis (FAS) type II, which uses discrete, nuclearly encoded proteins. Experimental evidence, obtained mainly through
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Metabolic integration of nutrient sensing in the central nervous system has been shown to be an important regulator of adiposity by affecting food intake and peripheral energy expenditure. Modulation of de novo fatty acid synthetic flux by cytokines and nutrient
Artículos
Fatty acid synthesis supports cancer cell proliferation, essential for membrane generation, protein modification, and bioenergetics.
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whats the appropriate solvent? PBS? DMSO? DW?
1 answer-
Helpful?
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Malonyl Coenzyme A can be store as aqueous solution ?
1 answer-
The stability of Malonyl Coenzyme A in aqueous solution has not been determined. However, other sources indicate that prepared solutions may be stable for several months at a minimum of -20 °C.
Helpful?
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