L4795

L-365260

≥98% (HPLC)

• Sinónimos: N-[(3R)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-N′-(3-methylphenyl)-urea
• Fórmula empírica (notación de Hill): C₂₄H₂₂N₄O₂
• Número de CAS: 118101-09-0
• Peso molecular: 398.46
• Código UNSPSC: 12352202
• ID de la sustancia en PubChem: 329817414
• NACRES: NA.77

Propiedades

• Ensayo: ≥98% (HPLC)
• Formulario: solid
• control farmacológico: regulated under CDSA - not available from Sigma-Aldrich Canada
• condiciones de almacenamiento: desiccated
• solubilidad: DMSO: >20 mg/mL
• emisor: Merck & Co., Inc., Kenilworth, NJ, U.S.
• temp. de almacenamiento: −20°C
• cadena SMILES: CN1C[C@H](NC(=O)Nc2cccc(C)c2)N=C(c3ccccc3)c4ccccc14
• InChI: 1S/C24H24N4O/c1-17-9-8-12-19(15-17)25-24(29)27-22-16-28(2)21-14-7-6-13-20(21)23(26-22)18-10-4-3-5-11-18/h3-15,22H,16H2,1-2H3,(H2,25,27,29)/t22-/m0/s1
• Clave InChI: LIVVMCBMGZZRRY-QFIPXVFZSA-N

Descripción

Acciones bioquímicas o fisiológicas

L-365260 is a CCK2 selective antagonist.

L-365260 is a CCK2 selective antagonist. Enhances amphetamine-induced stimulation of locomotor activity in rats (a model of drug abuse), inhibits thyroid carcinoma (TT)-cell proliferation (potential therapeutic implication for cancer treatment); bilateral injection into the medulla reverses both tactile allodynia and thermal hyperalgesia.

Características y beneficios

This compound is featured on the Cholecystokinin and Gastrin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• Pictogramas: GHS06,GHS09
• Palabra de señalización: Danger
• Frases de peligro: H301,H400
• Consejos de prudencia: P264 - P270 - P273 - P301 + P310 - P391 - P405
• Clasificaciones de peligro: Acute Tox. 3 Oral - Aquatic Acute 1
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable