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L133

Sigma-Aldrich

L-750,667 trihydrochloride

solid

Sinónimos:

3-[4-(4-Iodophenyl)piperazin-1-yl]methyl-1H-pyrrolo[2,3-b]pyridine trihydrochloride

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About This Item

Fórmula empírica (notación de Hill):
C18H19IN4 · 3HCl
Número de CAS:
1021868-80-3
Peso molecular:
527.66
UNSPSC Code:
12352202
PubChem Substance ID:
24278528
NACRES:
NA.77

form

solid

color

white

solubility

DMSO: 10 mg/mL

SMILES string

Cl.Cl.Cl.Ic1ccc(cc1)N2CCN(CC2)Cc3c[nH]c4ncccc34

InChI

1S/C18H19IN4.3ClH/c19-15-3-5-16(6-4-15)23-10-8-22(9-11-23)13-14-12-21-18-17(14)2-1-7-20-18;;;/h1-7,12H,8-11,13H2,(H,20,21);3*1H

InChI key

YOURSPNOEWYAKO-UHFFFAOYSA-N

Gene Information

human ... DRD4(1815)

Application

Useful in characterizing the extracellular domain of the D4 dopamine receptor.

Biochem/physiol Actions

Selective D4 dopamine receptor antagonist.

Caution

Hygroscopic

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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S Patel et al.
Molecular pharmacology, 50(6), 1658-1664 (1996-12-01)
We identified a novel azaindole derivative, L-750,667, that has high affinity (Ki = 0.51 nM) and >2000-fold selectivity for D4 dopamine receptors compared with its activity at D2 and D3 dopamine receptors. L-750,667 had little affinity for rat D1/D5 dopamine
Andrew M Bailey et al.
Journal of bacteriology, 192(6), 1607-1616 (2010-01-19)
The transcriptomes of Salmonella enterica serovar Typhimurium SL1344 lacking a functional ramA or ramR or with plasmid-mediated high-level overexpression of ramA were compared to those of the wild-type parental strain. Inactivation of ramA led to increased expression of 14 SPI-1
Margareta K Sorenson et al.
Proceedings of the National Academy of Sciences of the United States of America, 103(45), 16722-16727 (2006-11-01)
The dissociable sigma subunit of bacterial RNA polymerase is required for the promoter-specific initiation of transcription. When bound to RNA polymerase, sigma makes sequence-specific promoter contacts and plays a crucial role in DNA melting. In isolation, however, sigma lacks significant
J A Schetz et al.
Molecular pharmacology, 57(1), 144-152 (2000-01-05)
The molecular determinants that govern selective ligand binding to the rat D(4) dopamine receptor were investigated by substituting D(2) dopamine receptor sequences into a D(4) dopamine receptor background. The resulting mutant D(4) dopamine receptors were then screened with a panel
3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor.
J J Kulagowski et al.
Journal of medicinal chemistry, 39(10), 1941-1942 (1996-05-10)
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